. Author manuscript; available in PMC: 2021 Mar 1.

Published in final edited form as: J Hum Genet. 2020 Sep 18;66(3):297–306. doi: 10.1038/s10038-020-00843-4

Table 2.

Genetic association of diseases/traits and corresponding genes

Term	Count	p value	Genes
Diabetes, type 2	18	3.82E–06	SREBF1, HNF1B, KIF11, WFS1, LEPR, PPARG, IDE, FTO, IGF2BP2, CDKAL1, KCNJ11, TCF7L2, CRHR2, HNF4A, SLC2A2, GIPR, SLC30A8, ABCC8
Obesity	7	1.91E–02	SREBF1, CRHR2, GCKR, LEPR, FTO, PPARG, MC4R
Insulin	6	8.78E–04	LEPR, PPARG, IDE, KCNJ11, ABCC8, TCF7L2
Diabetes, gestational	5	5.79E–04	HNF4A, PPARG, KCNJ11, ABCC8, TCF7L2
Psoriasis	5	2.85E–02	GSTM1, CCHCR1, POU5F1, ZNF148, PPARG
Diabetes, type 2 triglycerides	3	5.97E–03	IGF2BP2, CDKAL1, SLC30A8
Laryngeal cancer	3	1.24E–02	GSTM1, CCND1, BCL2
Binge eating	2	3.47E–02	LEPR, MC4R
Diabetes, type 2 glucose insulin	2	3.47E–02	HNF4A, TCF7L2

The significant diseases (p < 0.05) are listed and sorted by the count of enriched pleiotropic genes. The corresponding p values and the specific genes are shown in the third and fourth columns. The pleiotropic genes are enriched in two major diseases: diabetes and obesity. Some genes such as “SREBF1,” “CRHR2,” “LEPR,” “FTO,” and “PPARG” are involved in both diseases