Table 4.
Expression data analysis of pleiotropic genes
| Pleiotropic analysis |
BMI |
Insulin resistant |
||||
|---|---|---|---|---|---|---|
| Gene | SNP | FDR | logFC | p value | logFC | p value |
| JAZF1 | rs849135 | 0.0002 | 1.76 | 1.39E–05 | 0.35 | 2.13E–05 |
| SYN2 | rs2119812 | 0.0018 | −1.99 | 5.49E–03 | −0.50 | 5.27E–04 |
| CDKN2C | rs12855 | 0.0227 | −5.57 | 1.99E–12 | −1.06 | 6.27E–11 |
| RABGAP1 | rs587364 | 0.0295 | −0.80 | 3.08E–03 | −0.15 | 7.46E–03 |
| UBE2E2 | rs17012823 | 0.0459 | 0.99 | 1.83E–04 | 0.14 | 8.22E–03 |
| ATP2B4 | rs17537593 | 0.0479 | −1.36 | 4.51E–03 | −0.38 | 7.26E–05 |
| DDX42 | rs11079511 | 0.0554 | −0.48 | 2.87E–02 | −0.14 | 1.67E–03 |
| EIF3H | rs12677487 | 0.0600 | −0.96 | 4.42E–05 | −0.22 | 2.13E–06 |
| NUCB2 | rs214105 | 0.0699 | 1.81 | 1.91E–05 | 0.39 | 5.18E–06 |
| SKIV2L | rs437179 | 0.0759 | −0.77 | 3.38E–03 | −0.13 | 1.20E–02 |
| BPTF | rs12449442 | 0.0839 | 0.94 | 3.65E–03 | 0.14 | 3.90E–02 |
| SENP2 | rs3087964 | 0.0876 | −1.92 | 2.05E–06 | −0.40 | 8.84E–07 |
| WDR68 | rs17631394 | 0.0899 | −0.74 | 3.16E–02 | −0.19 | 7.49E–03 |
| SOBP | rs3923954 | 0.1048 | 2.15 | 8.65E–06 | 0.53 | 3.62E–08 |
| SLIT3 | rs10069222 | 0.1096 | 0.78 | 4.54E–02 | 0.25 | 1.85E–03 |
| THADA | rs17334919 | 0.1108 | 1.66 | 2.17E–05 | 0.41 | 1.33E–07 |
| SLC39A11 | rs9912666 | 0.1145 | 2.08 | 3.78E–06 | 0.43 | 2.84E–06 |
| CCND1 | rs649392 | 0.1228 | 4.27 | 1.86E–09 | 0.78 | 8.58E–08 |
| BCL2 | rs12454712 | 0.1326 | −1.04 | 2.37E–03 | −0.26 | 1.72E–04 |
| OGDH | rs6961567 | 0.1342 | −1.22 | 1.38E–05 | −0.12 | 3.27E–02 |
| GALNT10 | rs6860445 | 0.1425 | 1.68 | 4.72E–05 | 0.29 | 4.68E–04 |
| PROS1 | rs8178610 | 0.1463 | 2.24 | 3.03E–10 | 0.45 | 3.39E–10 |
| PHACTR2 | rs1082 | 0.1543 | 0.64 | 3.10E–02 | 0.14 | 1.55E–02 |
| NOPE | rs2289045 | 0.1570 | −2.57 | 1.68E–05 | −0.43 | 4.02E–04 |
| HLA-DRA | rs3129882 | 0.1588 | 3.33 | 5.45E–09 | 0.63 | 7.17E–08 |
| FBXW7 | rs1516822 | 0.1633 | 1.42 | 3.96E–05 | 0.21 | 3.24E–03 |
| C15orf44 | rs12909511 | 0.1662 | −1.50 | 2.58E–03 | −0.28 | 4.84E–03 |
| PLEKHM2 | rs16851970 | 0.1771 | 0.82 | 5.05E–04 | 0.17 | 3.76E–04 |
| TOM1L2 | rs7222480 | 0.1872 | −2.73 | 3.83E–08 | −0.52 | 3.18E–07 |
The first column lists the 29 genes that show evidence of pleiotropy in both our study (FDR < 0.2) and the validation gene expression data (p < 0.05). The second and third columns list the corresponding SNPs and FDR value in our GWA-based pleiotropic analysis. The last four columns list the log fold change (FC) and p values in gene expression data which may reveal the association between genes and the phenotypes BMI and insulin resistance, respectively