Table 2.
Information of putative targets and topological attributes.
| No. | UniProt ID | Protein names | Gene names | Degree |
|---|---|---|---|---|
| 1 | P01375 | Tumor necrosis factor | TNF | 51 |
| 2 | P28482 | Mitogen-activated protein kinase 1 | MAPK1 | 45 |
| 3 | P01133 | Proepidermal growth factor | EGF | 45 |
| 4 | P00533 | Epidermal growth factor receptor | EGFR | 45 |
| 5 | P42574 | Caspase-3 | CASP3 | 45 |
| 6 | P04637 | Cellular tumor antigen p53 | TP53 | 44 |
| 7 | P35354 | Prostaglandin G/H synthase 2 | PTGS2 | 41 |
| 8 | P14780 | Matrix metalloproteinase-9 | MMP9 | 40 |
| 9 | P29474 | Nitric oxide synthase, endothelial | NOS3 | 40 |
| 10 | P05412 | Transcription factor AP-1 | JUN | 40 |
| 11 | P37231 | Peroxisome proliferator-activated receptor gamma | PPARG | 37 |
| 12 | P60484 | Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN | PTEN | 37 |
| 13 | P45983 | Mitogen-activated protein kinase 8 | MAPK8 | 36 |
| 14 | Q04206 | Transcription factor p65 | RELA | 35 |
| 15 | P35968 | Vascular endothelial growth factor receptor 2 | KDR | 33 |
| 16 | Q16539 | Mitogen-activated protein kinase 14 | MAPK14 | 33 |
| 17 | P08253 | 72 kDa type IV collagenase | MMP2 | 32 |
| 18 | P42345 | Serine/threonine-protein kinase mTOR | MTOR | 32 |
| 19 | P03372 | Estrogen receptor | ESR1 | 31 |
| 20 | P12821 | Angiotensin-converting enzyme | ACE | 28 |
| 21 | P01137 | Transforming growth factor beta-1 proprotein | TGFB1 | 27 |
| 22 | P16284 | Platelet endothelial cell adhesion molecule | PECAM1 | 27 |
| 23 | P42336 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | PIK3CA | 26 |
| 24 | P08254 | Stromelysin-1 | MMP3 | 25 |
| 25 | Q14790 | Caspase-8 | CASP8 | 25 |
| 26 | P09619 | Platelet-derived growth factor receptor beta | PDGFRB | 23 |
| 27 | Q00987 | E3 ubiquitin-protein ligase Mdm2 | MDM2 | 23 |
| 28 | P19438 | Tumor necrosis factor receptor superfamily member 1A | TNFRSF1A | 23 |
| 29 | P55211 | Caspase-9 | CASP9 | 22 |
| 30 | Q06124 | Tyrosine-protein phosphatase nonreceptor type 11 | PTPN11 | 22 |
| 31 | P41235 | Hepatocyte nuclear factor 4-alpha | HNF4A | 20 |
| 32 | P30556 | Type-1 angiotensin II receptor | AGTR1 | 20 |
| 33 | Q07869 | Peroxisome proliferator-activated receptor alpha | PPARA | 20 |
| 34 | P11511 | Aromatase | CYP19A1 | 16 |
| 35 | P35228 | Nitric oxide synthase, inducible | NOS2 | 16 |
| 36 | P49327 | Fatty acid synthase | FASN | 16 |
| 37 | O14920 | Inhibitor of nuclear factor kappa-B kinase subunit beta | IKBKB | 16 |
| 38 | P25116 | Proteinase-activated receptor 1 | F2R | 15 |
| 39 | P17252 | Protein kinase C alpha type | PRKCA | 15 |
| 40 | P07148 | Fatty acid-binding protein, liver | FABP1 | 15 |
| 41 | P15090 | Fatty acid-binding protein, adipocyte | FABP4 | 15 |
| 42 | P16109 | P-selectin | SELP | 14 |
| 43 | P11473 | Vitamin D3 receptor | VDR | 14 |
| 44 | P29350 | Tyrosine-protein phosphatase nonreceptor type 6 | PTPN6 | 14 |
| 45 | O95477 | Phospholipid-transporting ATPase ABCA1 | ABCA1 | 14 |
| 46 | P25101 | Endothelin-1 receptor | EDNRA | 13 |
| 47 | P55851 | Mitochondrial uncoupling protein 2 | UCP2 | 12 |
| 48 | P48736 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | PIK3CG | 12 |
| 49 | P05771 | Protein kinase C beta type | PRKCB | 12 |
| 50 | Q13464 | Rho-associated protein kinase 1 | ROCK1 | 12 |
| 51 | P20333 | Tumor necrosis factor receptor superfamily member 1B | TNFRSF1B | 12 |
| 52 | P15121 | Aldo-keto reductase family 1 member B1 | AKR1B1 | 11 |
| 53 | P21554 | Cannabinoid receptor 1 | CNR1 | 11 |
| 54 | P04629 | High affinity nerve growth factor receptor | NTRK1 | 11 |
| 55 | P22894 | Neutrophil collagenase | MMP8 | 11 |
| 56 | Q99814 | Endothelial PAS domain-containing protein 1 | EPAS1 | 10 |
| 57 | P10415 | Apoptosis regulator Bcl-2 | BCL2 | 10 |
| 58 | P32246 | C-C chemokine receptor type 1 | CCR1 | 8 |
| 59 | P11413 | Glucose-6-phosphate 1-dehydrogenase | G6PD | 8 |
| 60 | P08123 | Collagen alpha-2 | COL1A2 | 8 |
| 61 | P23219 | Prostaglandin G/H synthase 1 | PTGS1 | 8 |
| 62 | Q13133 | Oxysterols receptor LXR-alpha | NR1H3 | 8 |
| 63 | O75116 | Rho-associated protein kinase 2 | ROCK2 | 8 |
| 64 | Q03181 | Peroxisome proliferator-activated receptor delta | PPARD | 7 |
| 65 | P25105 | Platelet-activating factor receptor | PTAFR | 7 |
| 66 | P27169 | Serum paraoxonase/arylesterase 1 | PON1 | 7 |
| 67 | P17706 | Tyrosine-protein phosphatase nonreceptor type 2 | PTPN2 | 7 |
| 68 | O75469 | Nuclear receptor subfamily 1 group I member 2 | NR1I2 | 6 |
| 69 | P28223 | 5-Hydroxytryptamine receptor 2A | HTR2A | 6 |
| 70 | P12104 | Fatty acid-binding protein, intestinal | FABP2 | 6 |
| 71 | P02753 | Retinol-binding protein 4 | RBP4 | 5 |
| 72 | P39900 | Macrophage metalloelastase | MMP12 | 5 |
| 73 | P08235 | Mineralocorticoid receptor | NR3C2 | 5 |
| 74 | P11597 | Cholesteryl ester transfer protein | CETP | 5 |
| 75 | P07477 | Trypsin-1 | PRSS1 | 4 |
| 76 | Q07973 | 1,25-Dihydroxyvitamin D | CYP24A1 | 4 |
| 77 | P30542 | Adenosine receptor A1 | ADORA1 | 4 |
| 78 | P18054 | Polyunsaturated fatty acid lipoxygenase ALOX12 | ALOX12 | 4 |
| 79 | O00763 | Acetyl-CoA carboxylase 2 | ACACB | 4 |
| 80 | P04278 | Sex hormone-binding globulin | SHBG | 3 |
| 81 | P80365 | Corticosteroid 11-beta-dehydrogenase isozyme 2 | HSD11B2 | 3 |
| 82 | P13866 | Sodium/glucose cotransporter 1 | SLC5A1 | 2 |
| 83 | P35610 | Sterol O-acyltransferase 1 | SOAT1 | 1 |
| 84 | P05091 | Aldehyde dehydrogenase, mitochondrial | ALDH2 | 1 |