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. 2021 Feb 8;2021:6612796. doi: 10.1155/2021/6612796

Figure 2.

Figure 2

Signal transduction pathway of aromatase expression regulated by PGE2 through PGT. PGT is a trans-membrane domain transporter that carries extracellular PGE2 into cytoplasm, which activates the CAMP/PKA/CREB pathway by binding to its receptors EP2 and EP4, thus resulting in enhanced interaction between CREB, p300, and aromatase promoter I.3/II. PGE2 also decreased the amounts of BRCA1 and inhibited the interaction of BRCA1 and aromatase promoter I.3/II; then, CYP19 transcription and aromatase activity are enhanced ultimately.