Table 2.
Diagnostic accuracy of the AFP and PIVKA-II in HCC.
| Se (%) | Sp (%) | PPV (%) | NPV (%) | Accuracy (%) | AUC (95% CI) | Kappa | |
|---|---|---|---|---|---|---|---|
| HCC vs. all controls | |||||||
| AFP | 68.8 | 87.6 | 94.2 | 52.7 | 74.5 | 0.79 (0.74-0.84) | 0.48 |
| PIVKA-II | 89.0 | 91.7 | 96.5 | 76.4 | 89.7 | 0.90 (0.87-0.94) | 0.76 |
| AFP + PIVKA-II | 95.1 | 83.3 | 93.6 | 87.0 | 91.9 | 0.89 (0.85-0.93) | 0.80 |
| HCC vs. LC | |||||||
| AFP | 68.8 | 83.3 | 95.5 | 34.2 | 71.5 | 0.76 (0.70-0.82) | 0.33 |
| PIVKA-II | 89.0 | 90.0 | 97.9 | 61.4 | 89.2 | 0.89 (0.85-0.94) | 0.67 |
| AFP + PIVKA-II | 95.1 | 76.7 | 95.4 | 75.4 | 96.2 | 0.85 (0.78-0.92) | 0.71 |
Se: sensitivity; Sp: specificity; PPV: positive predictive value; NPV: negative predictive value; AUC: area under the curve; CI: confidence interval; AFP: alpha-fetoprotein; PIVKA-II: prothrombin induced by vitamin K absence II; LC: HBV-related liver cirrhosis.