Table 3.
Diagnostic accuracy of the AFP and PIVKA-II in early stage HCC.
| Se (%) | Sp (%) | PPV (%) | NPV (%) | Accuracy (%) | AUC (95% CI) | Kappa | |
|---|---|---|---|---|---|---|---|
| HCC vs. all controls | |||||||
| AFP | 60.9 | 89.2 | 83.8 | 71.3 | 75.6 | 0.75 (0.68-0.81) | 0.50 |
| PIVKA-II | 74.5 | 91.7 | 89.1 | 79.7 | 89.8 | 0.83 (0.77-0.89) | 0.67 |
| AFP + PIVKA-II | 83.3 | 89.1 | 89.3 | 83.1 | 86.1 | 0.86 (0.81-0.91) | 0.72 |
| HCC vs. LC | |||||||
| AFP | 60.9 | 83.3 | 87.0 | 53.8 | 68.8 | 0.72 (0.64-0.80) | 0.39 |
| PIVKA-II | 74.5 | 90.0 | 93.2 | 65.9 | 80.0 | 0.82 (0.75-0.88) | 0.60 |
| AFP + PIVKA-II | 83.3 | 76.7 | 87.7 | 69.7 | 81.2 | 0.82 (0.74-0.89) | 0.59 |
Se: sensitivity; Sp: specificity; PPV: positive predictive value; NPV: negative predictive value; AUC: area under the curve; CI: confidence interval; AFP: alpha-fetoprotein; PIVKA-II: prothrombin induced by vitamin K absence II; LC: HBV-related liver cirrhosis.