Figure 1.

Systolic home blood pressure (BP) by randomization group and follow-up duration. Data points are means. Vertical bars indicate 95% CI. Patients were randomized to initial monotherapy with losartan (LOS) 50–100 mg (N=151) or hydrochlorothiazide (HCTZ) 12.5–25 mg (N=150), crossing over at 8 weeks (switching to the alternative monotherapy), or initial combination treatment with losartan 50–100 mg plus hydrochlorothiazide 12.5–25 mg (N=304). In phase 2 (weeks 17–32), all patients received losartan 100 mg and hydrochlorothiazide 12.5 to 25 mg. In phase 3 (weeks 33–52), amlodipine with or without doxazosin could be added to achieve target BP. SBP indicates systolic BP. Reproduced from MacDonald et al²⁴ with permission. Copyright ©2017, Wiley.