Table 1.
Differential expression of genes caused by Porphyromonus gingivalis lipopolysaccharide (PgLPS) treatment only or PgLPS and trans-resveratrol in the IMR-32 neuroblastoma cells (fold change values ≥ 2.0 and ≤ − 2.0 folds are shown)
| Genes | Location | Type of molecules | PgLPS | PgLPS + trans-resveratrol |
|---|---|---|---|---|
| MYD88 innate immune signal transduction adaptor (MYD88) | Plasma membrane | Adapter protein | + 4.87 | − 2.96 |
| Tumor necrosis factor alpha (TNFA) | Extracellular space | Cytokine | + 4.39 | − 2.32 |
| Interleukin 1 beta (IL1B) | Extracellular space | Cytokine | + 4.61 | − 3.06 |
| Colony stimulating factor 1 (CSF1) | Extracellular space | Cytokine | + 5.34 | − 29.33 |
| Interleukin 6 (IL6) | Extracellular space | Cytokine | + 67.17 | − 11.30 |
| Interleukin 8 (IL8) | Extracellular space | Cytokine | + 22.51 | – |
| Colony stimulating factor 2 (CSF2) | Extracellular space | Cytokine | + 3.10 | + 10.96 |
| Interleukin 17A (IL17A) | Extracellular space | Cytokine | + 2.60 | + 9.82 |
| Prostaglandin-endoperoxide synthase 2 (PTGS2) | Cytoplasm | Enzyme | + 2.49 | − 2.71 |
| Insulin receptor substrate 1 (IRS1) | Cytoplasm | Enzyme | + 5.77 | + 4.78 |
| Glutathione S-transferase pi 1 (GSTP1) | Cytoplasm | Enzyme | − 3.13 | + 5.51 |
| TNF receptor associated factor 2 (TRAF2) | Cytoplasm | Enzyme | + 4.16 | − 12.25 |
| Adenosine deaminase (ADA) | Cytoplasm | Enzyme | + 4.71 | − 39.38 |
| FTO alpha-ketogluterate dependent dioxygenase (FTO) | Nucleus | Enzyme | + 4.26 | − 15.16 |
| Superoxide dismutase 1 (SOD1) | Cytoplasm | Enzyme | − 3.98 | + 3.06 |
| Superoxide dismutase 2 (SOD2) | Cytoplasm | Enzyme | − 3.21 | + 5.60 |
| Hydroxyacetyle Co-A dehydrogenase (HADH) | Cytoplasm | Enzyme | + 4.44 | − 23.79 |
| Prostaglandin E receptor 1 (PTGER1) | Plasma membrane | G-protein coupled receptor | + 2.72 | − 12.62 |
| Histamine receptor H3 (HRH3) | Plasma membrane | G-protein coupled receptor | + 6.25 | − 119.21 |
| Epidermal growth factor (EGF) | Extracellular space | Growth factor | – | + 9.31 |
| Insulin like growth factor 1 (IGF1) | Extracellular space | Growth factor | – | + 8.78 |
| Transforming growth factor beta 1 (TGFB1) | Extracellular space | Growth factor | − 4.84 | + 36.00 |
| Vascular endothelial growth factor A (VEGFA) | Extracellular space | Growth factor | – | − 13.35 |
| Phosphoenol pyruvate carboxylase 1 (PCK1) | Cytoplasm | Kinase | + 2.38 | + 9.67 |
| Colony stimulating factor 1 receptor (CSF1R) | Plasma membrane | Kinase | + 3.44 | + 5.70 |
| Interleukin 1 receptor associated kinase 1 (IRAK1) | Plasma membrane | Kinase | + 3.26 | − 68.45 |
| Glycogen synthase kinase 3 beta (GSK3B) | Nucleus | Kinase | + 4.40 | − 2.70 |
| Janus kinase 2 (JAK2) | Cytoplasm | Kinase | + 3.59 | − 61.71 |
| Phoshpoinositide-3 kinase regulatory subunit 1 (PIK3R1) | Cytoplasm | Kinase | + 6.08 | − 5.28 |
| Mitogen activated protein kinase kinase kinase 1 (MAP3K1) | Cytoplasm | Kinase | + 5.16 | − 6.10 |
| Inhibitor of nuclear factor kappa B kinase subunit beta (IKBKB) | Cytoplasm | Kinase | + 3.14 | − 10.25 |
| Interleukin 1 receptor associated kinase 2 (IRAK2) | Plasma membrane | Kinase | – | − 17.32 |
| AKT serine/threonine kinase 1 (AKT1) | Cytoplasm | Kinase | + 3.78 | − 78.92 |
| Insulin receptor (INSR) | Plasma membrane | Kinase | + 4.38 | − 47.27 |
| Nuclear receptor subfamily 4 group A member 2(NR4A2) | Nucleus | Ligan-dependent nuclear receptor | + 2.63 | − 2.96 |
| Dipeptidyl peptidase 4 (DPP4) | Plasma membrane | Peptidase | – | + 12.00 |
| Mucin 5AC, oligomeric mucus/gel-forming (MUC5AC) | Cytoplasm | Peptidase | – | + 22.46 |
| Plasminogen activator, tissue type (PLAT) | Extracellular space | Peptidase | + 2.87 | − 5.81 |
| Insulin degrading enzyme (IDE) | Extracellular space | Peptidase | + 7.03 | − 41.87 |
| Glucose-6 phosphatase catalytic subunit (G6PC) | Cytoplasm | Phosphatase | + 20.16 | − 2.03 |
| Early growth response 2 (EGR2) | Nucleus | Transcription regulator | + 3.31 | + 9.20 |
| Interferon regulatory factor 1 (IRF1) | Nucleus | Transcription regulator | + 2.32 | − 151.71 |
| Signal transducer and activator of transcription 1 (STAT1) | Nucleus | Transcription regulator | + 4.08 | − 14.09 |
| cAMP responsive element binding protein 1(CREB1) | Nucleus | Transcription regulator | + 6.13 | − 18.41 |
| Fos proto-oncogene, AP-1 transcription factor subunit (FOS) | Nucleus | Transcription regulator | + 12.90 | − 24.27 |
| Forkhead box O1 (FOXO1) | Nucleus | Transcription regulator | + 7.22 | − 42.19 |
| RELA proto-oncogene, NF-kB subunit (RELA) | Nucleus | Transcription regulator | + 2.22 | − 44.64 |
| Nuclear factor kappa B subunit 1 (NFKB1) | Nucleus | Transcription regulator | + 4.27 | − 48.93 |
| Signal transducer and activator of transcription 3 (STAT3) | Nucleus | Transcription regulator | + 2.81 | − 88.34 |
| Sterol regulatory element binding transcription factor 1 (SREBEF1) | Nucleus | Transcription regulator | + 4.23 | − 174.32 |
| Jun proto-oncogene, AP1 transcription factor subunit (JUN) | Nucleus | Transcription regulator | – | − 3.12 |
| Interleukin 6 receptor (IL6R) | Plasma membrane | Trans-membrane receptor | + 9.91 | − 2.62 |
| Leptin receptor (LEPR) | Plasma membrane | Trans-membrane receptor | − 2.17 | + 42.48 |
| CD40 molecule (CD40) | Plasma membrane | Trans-membrane receptor | + 4.53 | + 7.12 |
| Vascular cell adhesion molecule 1 (VCAM1) | Plasma membrane | Trans-membrane receptor | + 3.89 | − 3.57 |
| TNF receptor superfamily member 1A (TNFRSF1A) | Plasma membrane | Trans-membrane receptor | + 2.88 | − 19.77 |
| Insulin like growth factor 1 receptor (IGF1R) | Plasma membrane | Trans-membrane receptor | + 5.89 | − 64.43 |
| Uncoupling protein 2 (UCP2) | Cytoplasm | Transporter | + 6.51 | − 20.67 |
| TNF receptor associated factor 5 (TRAF5) | Cytoplasm | Transporter | + 3.91 | − 33.05 |
| Low density lipoprotein receptor (LDLR) | Plasma membrane | Transporter | + 3.19 | − 85.47 |
| Nucleotide binding oligomerization domain containing 2 (NOD2) | Cytoplasm | – | – | + 10.84 |
| Resistin (RETN) | Extracellular space | – | − 6.15 | + 8.10 |
| Adiponectin, C1Q and collagen domain containing (ADIPOQ) | Extracellular space | – | − 4.14 | + 6.66 |
| GRB2 associated binding protein 1 (GAB1) | Cytoplasm | – | + 7.40 | − 18.91 |