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. 2021 Jan 11;89(1):2–11. doi: 10.1007/s00239-020-09978-6

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© The Author(s) 2021

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Fig. 2 — Many biological reactions involve transformations of water. A total of 42% (2739/6520) of Enzyme Commission (EC) reactions use water as either a substrate or a product. The distribution of reactions among seven EC classes is shown, along with the portion of water-transforming reactions in each class