Table 1.

Studies of gray matter indices included in the systematic review, with summary statistics on the final row.

Cohort	References	CHR = 1, GHR = 2, PE = 3	HV (n)	HR (n)	HR-T (n)	HR-NT (n)	HR-S (n)	HR-NS (n)	Age of HR (yrs)	Follow up (yrs)	AP naive	Cortical thick-ness	Volume	Surface area	Quality: B/DO/CMC
Toho University	Katagiri et al. (15)	1	16	42	5	37			22.3	1
ADAPT	Damme et al. (16)	1	38	81					19	1
NAPLS	Cannon et al. (17)	1	135	274	35	239			19.3	1
	Chung et al. (18)	1	135	274	35	239			19.3	1
	Chung et al. (19)	1	132	267	37	230			19.3	2
Singapore	Ho et al. (20)	1	54	93			41	52	21.4	2
NIMH COS Study	Gogtay et al. (21)	2	52	52					16.2	10
	Mattai et al. (22)	2	86	43					13.4	6
	Zalesky et al. (23)	2	102	86					18	10
	Greenstein et al. (24)	2	110	80					14.9	10
	Mattai et al. (25)	2	79	78					14.9	10
Sibling pair, Utrecht	Brans et al. (26)	2	33	11					41.2	5
Twin pair, Utrecht	Hedman et al. (27)	2	54	19					38.7	5
Dutch Prediction of Psychosis	Ziermans et al. (28)	1	30	43	8	35			16.1	2
	de Wit et al. (29)	1	24	35			18	17	15.4	6
Edinburgh High Risk Study	Lawrie et al. (30)	2	20	66			19	47	23.1	2
	Job et al. (31)	2	19	65			18	47	21.4	2
	Mcintosh et al. (32)	2	36	146	17	72	57		21.2	10
	Bois et al. (33)	2	36	142	17	68	57		21	2
	Bois et al. (34)	2	36	142	17	68	57		21	2					-
Edinburgh Study of Comorbidity	Moorhead et al. (35)	3	45	53					15.9	1.5
	McKechanie et al. (36)	3	NA	43					16.2	6
FEPSY project	Walter et al. (37)	1	NA	23	10	13			24.2	5					-
	Walter et al. (38)	1	NA	18	8	10			25.7	5					-
	Borgwardt et al. (39)	1	NA	20	10	10			24.7	4
OASIS	Fusar-Poli et al. (40)	1	14	22	5	17			24.5	2
PACE	Pantelis et al. (41)	1	NA	21	10	11			19.7	3
	Sun et al. (42)	1	NA	35	12	23			19.9	4
	Takahashi et al. (43)	1	22	35	12	23			19.9	4
	Takahashi et al. (44)	1	20	31	11	20			19.9	4					-
Ludwig Maximilians	Koutsouleris et al. (45)	1	28	25	12	13			23.2	4
Western Psychiatric Institute and Clinic	Bhojraj et al. (46)	2	36	56					15.4	1					-
	Bhojraj et al. (47)	2	27	23					15.4	1
	Prasad et al. (48)	2	33	31					16.3	1
IMAGEN	Yu et al. (49)	3	NA	706					14.4	4
Dublin & Kildare	Calvo et al. (50)	3	25	25					13.5	2					-
Barcelona	Sugranyes et al. (51)	2	34	58					11.3	2.3
	Sugranyes et al. (52)	2	49	79			20	59	12.1	4
Totals:		17 GHR, 17 CHR, 4 PE	1560	3343	261	1128	287	222	Mean 19.7	Mean 3.9	19	14	26	9	Mean 1.4/3

GHR, Genetic high risk; CHR, Clinical high risk; T, transition; NT, no transition; S, symptomatic; NS, no symptoms; HR, high risk; HV, Healthy Volunteers; PE, psychotic experiences; AP, antipsychotic medication; NA, Not Applicable; Quality, Blind/Drop-Out Reported/Correct for Multiple Comparisons.