Figure 1.

Schematic representation of Immunodeficient mouse models and humanization strategies used to establish preclinical models. Tumor tissues from cancer patients are either injected (for hematological cancers) or implanted subcutaneously or orthotopically into immunodeficient mice with or without humanization. Scaffold implantation approach has also be used for hematological cancers in mice. Immunodeficient mouse models are either used for understanding the normal hematopoiesis or pathophysiology of the cancer tissues and for testing theurapeutic strategies. There are varying degrees of benefits for using different immunodeficient mouse models as depecited in the panel (+/−). IT, Immunotherapy, GVHD, Graft vs host disease, I.V., Intravenous route, BM, bone marrow, HSPC, hematopoietic stem and progenitor cells. Illustration was created with Biorender.com.