| Prkdc | gene encoding for protein kinase DNA-activated catalytic subunit which is required for the non-homologous end joining pathway of DNA repair during V(D)J recombination. Mutation of Prkdc leads to V(D)J recombination defects. |
| Sirpa | gene encoding for signal regulatory protein alpha; SIRPα acts as inhibitory receptor and interacts with the transmembrane protein CD47 also called the “don’t eat me” signal. This interaction negatively controls effector function of innate immune cells such as host cell phagocytosis. |
| Rag1 or Rag2 | recombination activating gene 1 or 2; the protein encoded by these genes are involved in antibody and T-cell receptor V(D)J recombination. |
| SCF | stem cell factor, is a cytokine that binds to the c-KIT receptor, and it plays a role in the regulation of HSCs in the niche by increasing the survival and self-renewal of HSCs. |
| GM-CSF | granulocyte macrophage colony stimulating factor; it stimulates stem cells to produce granulocytes and monocytes. |
| SRα | Simian virus 40 early promoter and the R segment and part of the U5 sequence of the long terminal repeat of human T cell leukemia virus type 1 |
| CSF2 | gene encoding for GM-CSF |
| FLT3-L | fms-related tyrosine kinase 3 ligand; is a hematopoietic cytokine; it stimulates the survival, proliferation, and differentiation of various blood cell progenitors. |
| CAR-T, CAR-NK | chimeric antigen receptor T-cell, chimeric antigen receptor NK-cell; CARs are receptor proteins that have been engineered to give T or NK cells the new ability to target a specific protein. The receptors are chimeric because they combine both antigen-binding and T/NK-cell activating functions into a single receptor. |