Table 1.
NLRP3 inflammasome-associated diseases
| Diseases | Relevance with the NLRP3 inflammasome | References |
|---|---|---|
| Alzheimer's disease | NLRP3 inflammasome activation by amyloid-β | (Halle et al. 2008) |
| Autoimmune diseases | ||
|
Multiple sclerosis (MS) Rheumatoid arthritis (RA) Systemic lupus erythematosus (SLE) |
NLRP3 gene SNP and increase of NLRP3, caspase-1, ASC, IL-1β, and IL-18 in MS patients Increased expression of NLRP3 inflammasome components in RA patients Controversial in a mouse model and SLE patients |
(Keane et al. 2018) (Kastbom et al. 2008) (Tsai et al. 2011) |
| Autoinflammatory diseases | ||
|
Cryopyrin-Associated Periodic Syndromes (CAPS) Familial cold autoinflammatory syndrome (FCAS) Muckle-Wells syndrome (MWS) Neonatal Onset Multisystemic Inflammatory Disease (NOMID)/Chronic Infantile Neurologic Cutaneous Articular (CINCA) |
Heterozygous gain-of-function mutations within the NLRP3 gene Increase of NLRP3, IL-1β, and IL-18 in CAPS patients |
(Masters et al. 2009) (Morandini et al. 2014) (Booshehri and Hoffman 2019) |
| Cancer | Different effects on tumor formation, development and invasion depending on the type and stage of cancer |
(El-Omar et al. 2000) (Snoussi et al. 2005) (Zaki et al. 2010) (Chen et al. 2013) (Bae et al. 2017) |
| Cardiovascular diseases | ||
|
Atherosclerosis Acute myocardial infarction |
Activation and inhibition study NLRP3 inflammasome activation by cholesterol crystals |
(Sandanger et al. 2013) (Duewell et al. 2010) |
| Gout | NLRP3 inflammasome activation by uric acid crystals | (Landis and Haskard 2001) |
| Nonalcoholic fatty liver disease (NAFLD) | Involvement in NASH/NAFLD patients and mouse models | (Dixon et al. 2012) |
| Silicosis | NLRP3 inflammasome activation by silica | (Hornung et al. 2008) |
| Skin diseases | ||
|
Acne Atopic dermatitis (AD) Psoriasis Vitiligo |
NLRP3 and caspase-1 activation by P. acnes in sebocytes Lowered NLRP3 and caspase-1 in lesional AD skin NLRP3 gene SNP in psoriatic lesions NLRP3 inflammasome activation by monobenzone in melanocytes |
(Li et al. 2014) (Dai et al. 2011) (Carlstrom et al. 2012) (van den Boorn et al. 2016) |
| Type 2 diabetes (T2D) |
The relevance of NLRP3, ASC, caspase-1 or IL-1β in T2D Studied in a high fat diet-induced obesity mouse model |
(Vandanmagsar et al. 2011) |