Table 1.
Patient demographics and baseline characteristics.
| Characteristic | Solid tumours (n = 47) | NC (n = 8) | DLBCL (n = 19) |
|---|---|---|---|
| Median age (min–max), years | 62 (26–84) | 48 (33–62) | 67 (49–82) |
| Male, n (%) | 19 (40.4) | 6 (75.0) | 14 (73.7) |
| ECOG PS, n (%)a | |||
| 0 | 12 (25.5) | 2 (25.0) | 4 (21.1) |
| 1 | 35 (74.5) | 5 (62.5) | 15 (78.9) |
| 2 | 0 | 1 (12.5) | 0 |
| Cancer type, n (%) | |||
|
Colorectal Prostate Breast Ovarian Salivary gland Metastatic prostate NSCLC Pancreatic Adenocarcinoma pancreas CUP Endometrial Fallopian tube Gastrointestinal stromal Hepatic Oesophageal Sarcoma Squamous cell carcinoma Uterine NC DLBCL |
11 (23.4) 7 (14.9) 5 (10.6) 4 (8.5) 4 (8.5) 2 (4.3) 2 (4.3) 2 (4.3) 1 (2.1) 1 (2.1) 1 (2.1) 1 (2.1) 1 (2.1) 1 (2.1) 1 (2.1) 1 (2.1) 1 (2.1) 1 (2.1) 0 0 |
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 (12.5)b 0 7 (87.5) 0 |
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 19 (100) |
| Median number prior systemic therapies (min–max), n | 5.0 (0–13) | 1.0 (0–1) | 3.0 (2–6) |
CUP poorly differentiated carcinoma of unknown origin, ECOG PS Eastern Cooperative Group performance status.
aPatients were required to have an ECOG PS of 0 or 1; however, one patient with NC with an ECOG PS of 2 was considered study eligible.
bNC is a rare and aggressive genetically defined subtype of squamous cell carcinoma characterised by chromosomal rearrangement of the NUT gene.