Table 2.

Toxicity grade ≥ 3 according to treatment arm.

Adverse events Grade ≥ 3	Arm A (chemo)		Arm B (chemo + cetux)
	N = 72		N = 78
Leukopenia/neutropenia	14	(19%)	23	(29%)
Febrile neutropenia	0	(0%)	2	(3%)
Thrombopenia	2	(3%)	4	(5%)
Anaemia	4	(6%)	5	(6%)
Skin toxicity	0	(0%)	14	(18%)
Mucositis	2	(3%)	2	(3%)
Diarrhoea	5	(7%)	5	(6%)
Nausea/vomiting	2	(3%)	2	(3%)
Increased liver enzymes	2	(3%)	1	(1%)
Other gastrointestinal events	3	(4%)	6	(8%)
Fatigue/decreased performance status	4	(6%)	7	(9%)
Thromboembolic events	4	(6%)	4	(5%)
Syncope/falls	0	(0%)	2	(3%)
Arrhythmia	0	(0%)	2	(3%)
Other cardiovascular events	5	(7%)	6	(8%)
Polyneuropathy	3	(4%)	4	(5%)
Hypersensitivity	2	(3%)	2	(3%)
Pain	12	(17%)	13	(17%)
Other neurological events	2	(3%)	2	(3%)
Hypomagnesaemia	0	(0%)	4	(5%)
Renal events	2	(3%)	0	(0%)
Other lab events	3	(4%)	2	(3%)
Ascites/pleural effusion	3	(4%)	2	(3%)
Infections	3	(4%)	5	(6%)
Other events	4	(6%)	2	(3%)