Table 2.

Associations of free form indoxyl sulfate and selected cardiovascular protein biomarkers in the multivariate linear regression model.

	β coefficient (95% CI)	p value
C–C motif chemokine 15	− 0.53 (− 0.71 to − 0.35)	< 0.001
Complement component C1q receptor	− 0.14 (− 0.20 to − 0.09)	< 0.001
Perlecan	− 0.05 (− 0.07 to − 0.03)	< 0.001
Bleomycin hydrolase	− 0.22 (− 0.34 to − 0.11)	< 0.001
CD166 antigen	− 0.15 (− 0.23 to − 0.07)	< 0.001
SLAM family member 5	− 0.13 (− 0.22 to − 0.05)	0.002
Fibroblast growth factor 23	0.63 (0.23–1.04)	0.002

Associations of baseline free form indoxyl sulfate with selected protein biomarker NPX value using multivariate linear regression model adjusting for age, sex, hemodialysis duration, cause of end-stage renal disease, arteriovenous shunt type, comorbidities (diabetes mellitus, hypertension, and dyslipidemia), medications (antiplatelet/warfarin, anti-hypertensive drugs, diabetic treatment drugs), and laboratory data (calcium, phosphate, high sensitivity C-reactive protein, and Kt/V).