Table 3.
Disease-free survival in the TransSCOT cohort and associations of clinicopathological features with GMS (n = 2912).
| Clinicopathological characteristics | Disease-free survival | GMS category | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| N (%)a | Univariate HR (95% CI) | P | Multivariate HR (95% CI) | P | 0 (n = 383) N (%)a |
1 (n = 1867) N (%) |
2 (n = 663) N (%) |
Pearson X2 | ||||
| Gender | ||||||||||||
| Female | 1135 (39) | 156 | (41) | 716 | (38) | 263 | (40) | 0.63 | ||||
| Male | 1778 (61) | 0.96 (0.83–1.11) | 0.60 | – | – | 227 | (59) | 1151 | (62) | 400 | (60) | |
| T-stage | ||||||||||||
| T1 | 78 (3) | 19 | (5) | 55 | (3) | 4 | (1) | <0.001 | ||||
| T2 | 250 (9) | 59 | (15) | 160 | (9) | 31 | (5) | |||||
| T3 | 1696 (58) | 227 | (60) | 1131 | (61) | 338 | (51) | |||||
| T4 | 889 (30) | 1.70 (1.51–1.91) | <0.001 | 1.74 (1.53–1.98) | <0.001 | 78 | (20) | 521 | (28) | 290 | (43) | |
| N-stage | ||||||||||||
| N0 | 556 (19) | 79 | (21) | 362 | (19) | 115 | (17) | 0.002 | ||||
| N1 | 1663 (57) | 224 | (58) | 1086 | (58) | 353 | (53) | |||||
| N2 | 694 (24) | 1.75 (1.57–1.96) | <0.001 | 1.73 (1.48–2.03) | <0.001 | 80 | (21) | 419 | (22) | 195 | (29) | |
| Site | ||||||||||||
| Colon | 2402 (82) | 310 | (81) | 1522 | (81) | 570 | (86) | 0.021 | ||||
| Rectum | 511 (18) | 0.69 (0.56–0.85) | <0.001 | – | 0.12 | 73 | (19) | 345 | (19) | 93 | (14) | |
| Risk group | ||||||||||||
| T1-3/N1 (lower risk) | 1284 (55) | 202 | (66) | 861 | (57) | 221 | (40) | <0.001 | ||||
| T4 and/or N2 (higher risk) | 1073 (45) | 2.45 (2.08–2.88) | <0.001 | – | 0.13 | 102 | (34) | 644 | (43) | 327 | (60) | |
| Adjuvant therapy | ||||||||||||
| FOLFOX | 846 (29) | 120 | (31) | 526 | (28) | 200 | (30) | 0.36 | ||||
| CAPOX | 2067 (71) | 1.08 (0.92–1.27) | 0.32 | – | – | 263 | (69) | 1341 | (72) | 463 | (70) | |
| Treatment time | ||||||||||||
| 3 months | 1469 (50) | 194 | (51) | 956 | (51) | 319 | (48) | 0.39 | ||||
| 6 months | 1444 (50) | 1.01 (0.88–1.16) | 0.85 | – | – | 180 | (49) | 911 | (49) | 344 | (52) | |
| GMS | ||||||||||||
| 0 | 300 (35) | – | – | – | – | |||||||
| 1 | 424 (49) | – | – | – | ||||||||
| 2 | 138 (16) | 1.48 (1.32–1.68) | <0.001 | 1.28 (1.12–1.47) | <0.001 | – | – | – | ||||
aPercentages rounded to nearest whole number and may not total 100%.
Emboldened values indicates p value < 0.05