Table 5.
Factors associated with disabilities in MSA patients.
| Risk factors | OR | Overall | (n = 81) | OR | MSA-C | (n = 50) | OR | MSA-P | (n = 31) |
|---|---|---|---|---|---|---|---|---|---|
| p† | OR 95% CI | p† | OR 95% CI | p† | OR 95% CI | ||||
| Age | |||||||||
| Symptom onset | 1.020 | 0.551 | 0.955–1.089 | 0.937 | 0.206 | 0.846–1.037 | 1.095 | 0.141 | 0.970–1.237 |
| Sex | |||||||||
| Woman | 3.889 | 0.008 | 1.428–10.591 | 3.058 | 0.121 | 0.745–12.5 | 10.7531 | 0.013 | 1.667–71.429 |
| Man | 1 | ||||||||
| Disease duration | 1.002 | 0.986 | 0.802–1.252 | 1.003 | 0.988 | 0.694–1.448 | 0.920 | 0.652 | 0.639–1.323 |
| Atrophy | |||||||||
| pons | 0.184 | 0.229 | 0.012–2.898 | 0.068 | 0.267 | 0.001–7.826 | 0.445 | 0.691 | 0.008–24.074 |
| MCP | 7.232 | 0.159 | 0.460–113.683 | 2.865 | 0.658 | 0.027–304.440 | 7.284 | 0.337 | 0.127–418.949 |
| HCB grade | |||||||||
| 1 | 0.005 | <0.001 | 0.001–0.041 | 0.000 | <0.001 | 0.000–0.005 | 0.016 | 0.031 | 0–0.686 |
| 2 | 0.016 | <0.001 | 0.002–0.100 | 0.002 | <0.001 | 0.000–0.026 | 0.121 | 0.232 | 0.004–3.864 |
| 3 | 0.019 | <0.001 | 0.003–0.116 | 0.012 | 0.001 | 0.001–0.164 | 0.010 | 0.008 | 0–0.295 |
| 4 | 0.068 | 0.002 | 0.013–0.371 | 0.028 | 0.004 | 0.003–0.311 | 0.088 | 0.132 | 0.004–2.080 |
| 5 | 1 | 1 | 1 | ||||||
†Based on Multinomial Ordinal logistic regression test, significance level of 0.05 (two-tailed). MSA-C multiple system atrophy (cerebellar subtype), MSA-P multiple system atrophy (parkinsonism subtype), MCP middle cerebellar peduncles, OR odds ratio.