Fig. 5. Polygenic risk scores and prediction.

A Polygenic risk score effect sizes for remission status (blue, odds ratios) and percentage symptom improvement (yellow, unstandardized betas). Error bars denote standard error of the mean. B Variance in remission status explained by the polygenic risk score regression results for cardioembolic risk (Malik et al., 2018). C, D Receiver operating curves for prediction of C remission status and D symptom improvement comparing a base clinical model to a model including the 11 polygenic risk scores. E Variable importance from the best performing model for remission status.