Table 3.

Distribution and Comparisons of hematological parameters among fetuses of different genotypes.

Items	α-thalassemia						β-thalassemia							Normal group (31 cases)	P c value
	α-thalassemia silent carrier (15 cases)	α-thalassemia trait (31 cases)	α-thalassemia intermedia (21 cases)	α-thalassemia major (69 cases)	Tota1 α-thalassemia (136 cases)	P a value	β0/βN (16 cases)	β+/βN (8 cases)	β+/β+ (3 cases)	β0/β0 (7 cases)	β0/β+ (15 cases)	Total β-thalassemia (49 cases)	P b value
Age (years)	27.40 ± 4.88	27.25 ± 5.69	26.71 ± 6.02	27.65 ± 5.37	27.39 ± 5.45	0.961	26.75 ± 7.64	27.00 ± 4.81	29.00 ± 3.74	28.57 ± 6.68	28.60 ± 5.34	27.87 ± 5.93	0.610	30.10 ± 6.51	0.050
Gestational age (weeks)	29.40 ± 2.41	28.22 ± 2.28	28.90 ± 3.52	28.67 ± 2.25	28.68 ± 2.50	0.484	30.38 ± 3.85	29.00 ± 2.27	32.00 ± 5.89	23.86 ± 1.77	24.47 ± 3.36	27.76 ± 4.45	< 0.001	28.77 ± 3.46	0.103
HbF (%)	91.49 ± 3.01	83.75 ± 9.88	61.76 ± 10.13	–	78.67 ± 14.71	< 0.001	96.40 ± 1.66	96.76 ± 0.74	97.05 ± 4.89	100 ± 0	99.69 ± 0.83	98.00 ± 2.28	< 0.001	93.08 ± 2.54	< 0.001
HbA (%)	7.74 ± 2.69	9.46 ± 3.71	11.61 ± 3.46	–	9.75 ± 3.67	0.005	3.58 ± 1.67	3.24 ± 0.74	5.90 ± 6.08	–	1.15 ± 1.38	3.32 ± 2.05	< 0.001	6.92 ± 2.54	< 0.001
Hb Barts (%)	0.81 ± 0.66	4.71 ± 2.81	23.52 ± 5.63	86.70 ± 3.48	47.96 ± 39.34	< 0.001	–	–	–	–	–	–	–	–	–
RBC (10*12/L)	3.99 ± 1.11	3.89 ± 0.78	3.65 ± 0.84	3.02 ± 0.57	3.43 ± 0.84	< 0.001	3.90 ± 0.45	3.72 ± 0.45	3.68 ± 0.30	3.25 ± 0.29	3.23 ± 0.34	3.58 ± 0.47	0.003	3.59 ± 0.53	0.446
Hb (g/L)	127.53 ± 11.56	117.31 ± 22.61	91.14 ± 17.35	69.96 ± 11.39	90.87 ± 27.88	< 0.001	139.50 ± 16.80	139.25 ± 11.16	135.33 ± 20.21	127.71 ± 8.07	125.86 ± 10.17	133.02 ± 13.33	0.086	129.42 ± 15.94	< 0.001
HCT (%)	42.02 ± 10.57	38.42 ± 7.13	32.68 ± 5.29	29.65 ± 4.85	33.58 ± 7.79	< 0.001	42.79 ± 4.15	41.93 ± 3.39	40.50 ± 6.20	39.51 ± 2.36	38.29 ± 2.86	40.69 ± 3.71	0.074	39.79 ± 4.72	< 0.001
MCV (fL)	105.78 ± 4.46	99.89 ± 10.06	91.59 ± 11.09	98.69 ± 7.76	98.66 ± 9.35	< 0.001	110.24 ± 7.16	113.11 ± 6.86	109.57 ± 7.87	122.11 ± 7.87	119.20 ± 7.55	114.43 ± 8.86	0.020	111.93 ± 11.28	< 0.001
MCH (pg)	33.03 ± 4.39	30.34 ± 1.98	25.36 ± 2.87	23.21 ± 1.74	26.33 ± 4.42	< 0.001	35.91 ± 3.10	37.55 ± 2.09	36.63 ± 2.48	39.47 ± 2.33	39.15 ± 2.28	37.40 ± 3.00	0.031	36.51 ± 3.79	< 0.001
MCHC (g/L)	296.80 ± 64.85	304.69 ± 13.60	277.95 ± 18.02	235.37 ± 11.53	265.25 ± 39.38	< 0.001	325.79 ± 18.23	332.00 ± 3.25	334.67 ± 1.53	323.29 ± 7.39	328.79 ± 12.00	327.00 ± 13.00	0.560	326.10 ± 10.74	< 0.001
RDW (%)	15.54 ± 1.26	16.81 ± 3.18	19.77 ± 3.64	26.76 ± 5.25	22.07 ± 6.42	< 0.001	16.31 ± 1.21	16.50 ± 0.69	16.63 ± 1.27	16.04 ± 0.63	16.01 ± 1.20	16.13 ± 1.04	0.451	15.78 ± 1.15	< 0.001
NRBCs (%)	13.65 (8.48–20.13)	11.3 (5.00–24.90)	29.6 (13.93–77.10)	1540.7 (1055.75–2049.00	212.80 (14.00–1555.00)	< 0.001	9.90 (6.60–23.20)	13.0 (6.30–18.0)	5.05 (2.80–7.30)	22.35 (11.2–37.85)	11.0 (9.10–23.30)	12.70 (7.30–25.40)	0.012	2.5 (0.1405–5.875)	< 0.001

P^a: Comparison among 4 α-thalassemia subgroups using ANOVA test for all the hematological parameters except for the NRBCs using Kruskal–Wallis test; P^b: comparison among 5 β-thalassemia subgroups using ANOVA test for all the hematological parameters except for the NRBCs using Kruskal–Wallis test; P^c: comparison among all the α-thalassemia cases, all the β-thalassemia cases and normal group using ANOVA test for all the hematological parameters except for the NRBCs using Kruskal–Wallis test. Significant differences (P < 0.05) are indicated in bold.