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. 2021 Feb 15;11:3809. doi: 10.1038/s41598-021-83157-5

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Scatterplot of activated partial thromboplastin time (APTT) depicted longitudinally and subdivided according to brain infarction status. Samples were collected during the first month of treatment or until BI detection. The red line represents patients that suffered brain infarction on ECMO, the blue line represents patients with no signs of infarction. The line indicates a LOWESS curve and the shaded area surrounding it indicates 95% confidence intervals. The graph was created using ggplot 2 (Wickham H. ggplot2: Elegant Graphics for Data Analysis, 2016. NY: Springer-Verlag).