Table 1.
Univariate regression analysis predicting brain infarction during extracorporeal membrane oxygenation.
| Variable | BI (n = 41) | No BI (n = 234) | p-value |
|---|---|---|---|
| Pre-cannulation data | |||
| Age (years) | 49 (38–58) | 54 (35–62) | 0.516 |
| Male sex | 26 (62%) | 146 (62%) | 0.952 |
| Weight (kg) | 82 (± 23), (2 missing, 5%) | 83 (± 19), (7 missing, 3%) | 0.859 |
| Smoking | 6 (14%) | 42 (18%) | 0.646 |
| CCI | 0.5 (0–2) | 0 (0–1) | 0.972 |
| SAPS-3 | 84 (± 14), (8 missing, 19%) | 78 (± 14), (48 missing, 21%) | 0.026 |
| GCS | 13 (3–15), (8 missing, 19%) | 13 (6–15), (48 missing, 21%) | 0.090 |
| SOFA total | 14 (10–16), (11 missing, 26%) | 13 (10–15), (60 missing, 26%) | 0.286 |
| SOFA coagulation | 0 (0–2), (9 missing, 21%) | 1 (0–2), (54 missing, 23%) | 0.712 |
| Cardiac arrest | 14 (33%) | 40 (17%) | 0.017 |
| ABG analysis | |||
| pH | 7.22 (7.09–7.33), (3 missing, 7%) | 7.23 (7.14–7.31), (15 missing, 6%) | 0.638 |
| PaCO2 (kPa) | 6.92 (5.34–8.99), (1 missing, 2%) | 7.18 (5.9–9.2), (16 missing, 7%) | 0.807 |
| PaO2 (kPa) | 7.45 (6.30–8.45), (3 missing, 7%) | 7.60 (6.5–9.3), (16 missing, 7%) | 0.155 |
| p-lactate | 4.00 (1.85–7.5), (5 missing, 12%) | 2.75 (1.56–5.64), (23 missing, 10%) | 0.113 |
| ECMO data | |||
| VA ECMO | 30 (73%) | 137 (50%) | 0.002 |
| Atrial fibrillation/flutter | 12 (29%) | 55 (24%) | 0.482 |
| Extracranial thrombosis | 3 (7%) | 21 (9%) | 0.699 |
| Extracranial bleeding | 25 (60%) | 124 (53%) | 0.435 |
| ECMO circuit change | 12 (29%) | 59 (25%) | 0.647 |
| Conversion of modality | 12 (29%) | 34 (15%) | 0.028 |
| Time until BI (days) | 3 (2–6) | – | – |
Normally distributed continuous data are presented as mean (± 1 SD), non-parametric continuous data as median (interquartile range) and categorical data as count (proportion).
Bold text in the p value column indicates a statistically significant correlation (p < 0.05).
ABG arterial blood gas, BI brain infarction, CCI Charlson comorbidity index, ECMO extracorporeal membrane oxygenation, GCS Glasgow Coma Scale, SAPS-3 Simplified Acute Physiology Score III, SOFA Sequential Organ Failure Assessment, VA venoarterial.