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. 2021 Feb 15;11:3828. doi: 10.1038/s41598-021-83270-5

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Selection of Optimal Predictor and Decision Threshold Based on Maximum Weighted Youden Index (J_w): From the mean value from 2 to 10 min of CPR, the optimal decision threshold was selected by maximum ROSC prediction performance, as assessed by the weighted Youden index (J_w). For each parameter, the sensitivity (blue, left y-axis) and specificity (purple, left y-axis) for ROSC, and the calculated Youden J_w (bold black line, right y-axis) are plotted for all possible threshold values (x-axis). The parameter-specific maximum J_w is highlighted by a circle with a dotted line drawn to the corresponding threshold value on the x-axis; these values are listed in Table 3. Δ[HbO₂]_CPR achieved the highest J_w (0.96) overall; this corresponds to a decision threshold of + 1.3 µmol/L.