Figure 5.

Time-Dependent Prediction Performance during Early CPR: The predictive performance of the optimal decision threshold (Δ[HbO₂]_CPR ≥  + 1.3 µmol/L), across 10 independent test folds, is summarized (median, horizontal line; interquartile range, box; range, whisker) minute-to-minute from 2 to 10 min of CPR. Within each 1-min interval, the decision threshold was applied to predict ROSC in each test fold and the corresponding specificity (top left), sensitivity (bottom left), accuracy (bottom right), and J_w (top right) were calculated. This provides a realistic rendering of the variability and time-dependence of the predictive performance of Δ[HbO₂]_CPR. For comparison, the parameter’s max J_w derived from mean 2–10 min CPR values, is overlaid in the J_w sub-panel as a horizontal cyan line. A median specificity of 1, median sensitivity > 0.5, and a median Youden J_w > 0.9 is achieved at all time points.