Table 2.
Summary of cerebral hemodynamic parameters at baseline, end-of-asphyxia and at 10-min of CPR.
| ROSC, n = 37 Median [IQR] |
No-ROSC, n = 11 Median [IQR] |
p value | |
|---|---|---|---|
| Baseline | |||
| [HbO2], μmol/L | 33.4 [29.1, 36.9] | 35.1 [28.8, 45.7] | 0.317 |
| [Hb], μmol/L | 30.9 [26.8, 36.4] | 32.4 [30.3, 36.4] | 0.443 |
| THC, μmol/L | 66.1 [57.5, 69.7] | 69.5 [58.9, 76.1] | 0.330 |
| StO2, % | 49.7 [47.4, 56.2] | 53.0 [47.8, 55.4] | 0.687 |
| Asphyxia, End | |||
| [HbO2], µmol/L | 20.2 [15.6, 24.5] | 24.0 [20.3, 25.6] | 0.155 |
| [Hb], µmol/L | 47.9 [43.3, 56.2] | 55.3 [41.3, 57.5] | 0.659 |
| THC, µmol/L | 66.7 [63.0, 76.0] | 78.2 [60.6, 82.8] | 0.462 |
| StO2, % | 28.4 [25.0, 32.3] | 31.4 [29.0, 34.8] | 0.177 |
| CPR, 10 min | |||
| [HbO2], µmol/L | 29.1 [21.7, 33.1] | 20.8 [16.1, 23.9] | 0.007 |
| Δ[HbO2] from Baseline | − 5.3 [− 11.3, − 1.3] | − 18.5 [− 24.5, − 8.0] | < 0.001 |
| r[HbO2] to Baseline, % | 84.6 [71.0, 95.6] | 52.2 [39.1, 71.9] | 0.001 |
| Δ[HbO2] from 1 min-CPR | + 4.4 [2.1, 7.8] | − 3.6 [− 9.5, − 0.7] | < 0.001 |
| r[HbO2] to 1 min-CPR, % | 120.0 [110.5, 141.1] | 87.0 [63.3, 95.4] | < 0.001 |
| [Hb], µmol/L | 41.7 [37.8, 47.1] | 43.8 [37.1, 49.6] | 0.477 |
| Δ[Hb] from Baseline | + 9.8 [7.2, 13.7] | + 11.0 [6.5, 17.2] | 0.745 |
| r[Hb] to Baseline, % | 131.2 [121.5, 145.2] | 127.5 [122.2, 153.1] | 0.845 |
| Δ[Hb] from 1 min-CPR | − 2.3 [− 7.0, − 0.2] | − 2.6 [− 6.7, 0.5] | 1.000 |
| r[Hb] to 1 min-CPR, % | 94.3 [86.0, 99.6] | 93.0 [86.8, 102.0] | 0.825 |
| StO2, % | 39.8 [35.1, 44.8] | 31.1 [28.0, 35.8] | 0.003 |
| ΔStO2 from Baseline | − 12.4 [− 16.2, − 5.6] | − 23.5 [− 27.0, − 13.5] | 0.004 |
| rStO2 to Baseline, % | 76.0 [68.9, 89.8] | 54.8 [50.0, 74.3] | 0.003 |
| ΔStO2 from 1 min-CPR | + 6.6 [3.4, 9.1] | − 3.9 [− 6.5, − 0.8] | < 0.001 |
| rStO2 to 1 min-CPR, % | 118.1 [108.9, 130.6] | 90.4 [80.5, 96.4] | < 0.001 |
| THC, µmol/L | 68.6 [62.9, 78.2] | 60.7 [55.5, 71.8] | 0.059 |
| ΔTHC from Baseline | + 6.1 [2.3, 9.4] | − 2.3 [− 15.6, 3.8] | 0.002 |
| rTHC to Baseline, % | 109.6 [103.6, 115.0] | 95.9 [78.9, 105.3] | 0.001 |
| ΔTHC from 1 min-CPR | + 1.7 [− 1.3, 6.1] | − 5.4 [− 18.0, − 2.1] | 0.001 |
| rTHC to 1 min-CPR, % | 102.5 [98.0, 108.9] | 93.1 [78.6, 96.9] | 0.002 |
[HbO2], oxy-hemoglobin concentration; [Hb], deoxy-hemoglobin concentration; StO2, tissue oxygen saturation; THC, total hemoglobin concentration; Δ-prefix, absolute change; r-prefix, relative value compared to 100% at baseline.