Table 3.
Predictive performance and optimal decision threshold for significant cerebral hemodynamic parameters.
| Significant parameters | AUC (95% CI) | Jw | Decision threshold | 10-fold cross-validation | |
|---|---|---|---|---|---|
| Decision threshold [Min, Max] |
Jw Median [IQR] |
||||
| [HbO2], µmol/L | 0.68 (0.50, 0.82) | 0.86 | 31.4 | [30.2, 33.4] | 0.83 [0.80, 0.87] |
| Δ[HbO2] from 1 min-CPR | 0.94 (0.83, 0.98) | 0.96 | + 1.3 | [+ 1.3, + 1.9] | 0.95 [0.93, 1.00] |
| r[HbO2] to 1 min-CPR, % | 0.91 (0.76, 0.97) | 0.90 | 121.5 | [105.5, 121.9] | 0.90 [0.87, 0.90] |
| StO2, % | 0.70 (0.50, 0.85) | 0.84 | 45.5 | [44.2, 46.2] | 0.80 [0.80, 0.83] |
| ΔStO2 from 1 min-CPR | 0.92 (0.81, 0.97) | 0.95 | + 2.1 | [+ 1.9, + 2.4] | 0.94 [0.93, 0.95] |
| rStO2 to 1 min-CPR, % | 0.90 (0.74, 0.97) | 0.90 | 114.7 | [105.3, 115.3] | 0.87 [0.80, 0.93] |
| THC, µmol/L | 0.59 (0.38, 0.78) | 0.81 | 95.8 | [93.2, 95.8] | 0.80 [0.80, 0.80] |
| ΔTHC from 1 min-CPR | 0.83 (0.66, 0.93) | 0.89 | + 3.4 | [+ 2.3, + 3.6] | 0.88 [0.86, 0.94] |
| rTHC to 1 min-CPR, % | 0.80 (0.60, 0.91) | 0.85 | 108.1 | [104.0, 109.6] | 0.80 [0.38, 0.82] |
AUC = area under curve of receiver-operating-characteristic; Jw = maximum weighted Youden J index; [HbO2] = oxy-hemoglobin concentration; StO2 = tissue oxygen saturation; THC = total hemoglobin concentration; Δ-prefix = absolute change; r-prefix = relative value compared to 100% at baseline.