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. 2021 Feb 15;11:3802. doi: 10.1038/s41598-021-82937-3

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Palladin iso4 is required for CAFs to sustain inflammatory features. (a) Measurement of secreted cytokines TGFβ1, IL-6, and IL-8 by palladin KD CAFs normalized to cell number via RFLP expression and compared to control CAF secretions using assorted CAF conditioned media at the end of 5 days ECM production (see “Materials and methods” for additional details). (b) Gene expression RT-qPCR transcript analysis of TGFB1 (TGFβ1), IL6 (IL-6), and CXCL8 (IL-8) in palladin KD CAFs, compared to control CAF at the end of 5 days d-ECM production. Data presented were derived from a minimum of 4 experimental replicates of biological duplicates (n = 8). One Way ANOVA, Dunnett’s multiple comparison test was performed to determine statistical significance compared to control CAFs. *p < 0.05; ** p < 0.01; ***p < 0.001; **** p < 0.0001.