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. 2021 Feb 2;9:635728. doi: 10.3389/fcell.2021.635728

Figure 4.

Figure 4

RBM14 depletion leads to abnormal spindle morphology and chromosome misalignment in mouse oocytes. (A) Confocal images of control and RBM14-depleted oocytes. Green = α-tubulin-FITC antibody, blue = DNA (Hoechst 33342). In control oocytes, meiotic spindles presented normal barrel-shaped morphologies and well-aligned chromosomes. In RBM14-MO injected oocytes, meiotic spindles presented abnormal morphology (e.g., apolar and malformed) and irregularly scattered chromosomes. Scale bar = 20 μm. (B) Percentage of oocytes with spindle/chromosome defects. Data are mean ± SEM of three independent experiments. **P < 0.01.