Table 2.

Outcomes evaluated in 26 clinical mastitis treatment trials.

Study	Bact. cure	New IMI	Clinical cure	SCC	Recurrence	Milk yield	Culling
NEGATIVELY CONTROLLED RANDOMIZED CLINICAL TRIALS
Roberson et al. (39)	NSDa	NSD	NSD	SIGb	Defined as CC NSD	SIG
Suojala et al. (27)	NSD		NSD at day 21	No stats			NSD
Schukken et al. (40)	SIG		SIG	NSD		NSD	SIG
Persson et al. (41)				SIG
Fuenzalida and Ruegg (22)		NSD	NSD	NSD	NSD	NSD	NSD
Fuenzalida and Ruegg (25)	SIG		NSD	NSD	NSD	NSD	NSD
POSITIVELY CONTROLLED TRIALS – NOT TESTING A NON-INFERIORITY HYPOTHESIS
Erskine et al. (34)			NSD
Wraight (42)	NSD		NSD
McDougall (43)	NSD		SIG	NSD	SIG	NSD
Taponen et al. (44)	NSD		NSD
Sérieys et al. (45)	NSD		NSD	SIG
Taponen et al. (46)	SIG		NSD
Wenz et al. (33)	NSD				NSD		NSD
Bradley and Green (47)	NSD	NSD
Swinkels et al. (48)	NSD	NSD	SIG	NSD
Kalmus et al. (49)	NSD		NSD	NSD			NSD
Truchetti et al. (50)	SIG	NSD	NSD
Cortinhas et al. (51)	NSD	NSD	NSD
Viveros et al. (52)	NSD		SIG	SIG
McDougall et al. (53)	NSD		SIG	NSD
POSITIVELY CONTROLLED TRIALS – TESTING A NON-INFERIORITY OR “EQUIVALENCY” HYPOTHESIS
McDougall et al. (54)	NSD		SIG		Defined as CC
McDougall et al. (21)	NSD		SIG	NSD	Defined as CC	NSD	NSD
Schukken et al. (55)	NIc		NSD				NI
Vasquez et al. (56)	NI		NI	NI			NI
Bryan et al. (57)	NSD		NSD		Defined as CC
Tomazi et al. (58)	Inconclusive		Inconclusive	NI

^aNo significant difference;

^bstatistically significant difference among treatments;

^cnon-inferior.