Table 3.
Bacteriological cure (BC) definitions and outcomes for 24 studies reporting this outcome.
| Study | Bacteriological cure definition | % BCa | Treatment effects |
|---|---|---|---|
| NEGATIVELY CONTROLLED RANDOMIZED CLINICAL TRIALS | |||
| Roberson et al. (39) | Etiology absent 3 consecutive days at 7 & 36 d | 67.0% 45.0% 53.0% 55.0% |
No |
| Suojala et al. (27) | No E. coli at d 2 or d 21 | 90.5% 86.8% |
Not at d 21 |
| Schukken et al. (40) | Etiology absent at d 7 & 14; if samples missing failure was defined | 73.0% 38.0% |
Yes |
| Persson et al. (41) | Etiology absent at d 3 & 28 | 88.5% 84.2% |
No statistics performed |
| Fuenzalida and Ruegg (25) | Etiology absent at 7, 14, 21, 28 d samples | 70.3% 77.8% 51.2% |
Yes |
| POSITIVELY CONTROLLED TRIALS – NOT TESTING A NON-INFERIORITY HYPOTHESIS | |||
| Wraight (42) | Only assessed if CC achieved; Etiology absent from all 3 post-treatment samples | 75.0% 64.3% |
No |
| McDougall (43) | Etiology absent in 21 d sample | 77.0% 77.0% |
No |
| Taponen et al. (44) | Etiology absent in 26 d sample | 73.2% 78.7% |
No |
| Sérieys et al. (45) | Etiology absent at both 17 & 22 d | 54.3% 45.9% |
No |
| Taponen et al. (46) | Etiology absent in 21- 28 d samples | 56.1% 79.1% 33.3% 33.3% |
Yes |
| Wenz et al. (33) | Culture negative 7 d after leaving hospital | 27.0% 45.0% 33.0% 52.0% |
No |
| Bradley and Green (47) | Etiology absent in both 16 and 25 d | Not reported | No |
| Swinkels et al. (48) | Etiology absent in both 14 and 21 d samples | 72.0% 79.0% |
No |
| Kalmus et al. (49) | PCR negative at d 21 & 28 | 54.1% 55.7% |
No |
| Truchetti et al. (50) | Etiology negative at d 7, 14, & 21 | 32.0% 61.0% |
Yes |
| Cortinhas et al. (51) | Etiology absent at 14 or 21 d | 79.0% 76.0% |
No |
| Viveros et al. (52) | Etiology absent in 7, 14 & 21 d samples | 90.0% 95.1% 88.9% 83.3% |
No |
| McDougall et al. (53) | Etiology absent in both 14 & 21 d | 81.2% 83.8% |
No |
| POSITIVELY CONTROLLED TRIALS – TESTING A NON-INFERIORITY OR “EQUIVALENCY” HYPOTHESIS | |||
| McDougall et al. (54) | Etiology absent at 21 d | 84.0% 81.0% 85.0% |
yes |
| McDougall et al. (21) | Etiology absent in both 14 and 21 d samples | 73.3% 72.0% |
No |
| Schukken et al. (55) | Etiology absent at d 10 and 17 | 61.0% 73.0% |
No |
| Vasquez et al. (56) | Etiology absent at 14, 21 d samples | 72.0% 67.0% |
No |
| Bryan et al. (57) | Only assessed if CC achieved; Etiology absent at d 9,16, & 23 | 57.2% 65.7% |
No |
| Tomazi et al. (58) | Etiology absent in 14 and 21 d samples | 68.0% 73.0% |
No |
a
Proportion of BC are listed in same order of treatments defined in Table 1.