Table 1.
Demographics and SSc Characteristics comparing patients with a history of cancer to those who have never had a cancer. Patients with cancer history are more likely to be Caucasian, older at SSc onset, and have a higher Modified Rodnan Skin Score (MRSS).
| Patient Characteristics | No History of Cancer (N=401) | *Cancer History (N=309) | p-value |
|---|---|---|---|
| n (%) / median (IQR) | n (%) / median (IQR) | ||
| Sex | 345 (86) | 254 (82) | 0.1760 |
| Hispanic Ethnicity | 18 (9) | 3 (2) | 0.0020 |
| Race | |||
| Caucasian | 292 (73) | 277 (89) | <0.0001 |
| African American | 81 (20) | 23 (7) | |
| History of smoking (ever) | 185 (47) | 161 (52) | 0.1490 |
| Age at SSc-symptom onset (RP or non-RP) (IQR) | 39.5 (28–49) | 48.2 (38–58) | <0.0001 |
| Meets ACR 2013 Criteria | 387 (97) | 300 (97) | 1.0000 |
| Follow-up Duration (yrs) | 14.4 (9–24) | 12.6 (6–23) | 0.0969 |
| Disease Duration Upon Cohort Entry | 6.5 (2.6–15) | 4.9 (1.5–15) | 0.0740 |
| Cutaneous Subtype | |||
| Sine | 13 (3) | 9 (3) | 0.2730 |
| Limited | 214 (53) | 144 (46) | |
| Type II Skin | 36 (9) | 33 (11) | |
| Diffuse | 138 (34) | 124 (40) | |
| Cutaneous Subtype (limited vs diffuse) | 138 (34) | 124 (40) | 0.1170 |
| Maximum Modified Rodnan Skin Score | 6 (3–17) | 9 (4–20) | 0.0030 |
| History of scleroderma renal crisis | 16 (4) | 19 (6) | 0.2220 |
| Minimum FVC % predicted over follow-up (n=668/710) | 70 (54–84) | 70 (57–84) | 1.0000 |
| Maximum Right Ventricular Systolic Pressure (n=590/710) | 37 (32–50) | 40 (33–53) | 0.0700 |
| Pulmonary Hypertension (mean PAP>20) (n=148) | 60 (15) | 41 (13) | 0.5880 |
| Pulmonary Hypertension (mean PAP>24) (n=148) | 54 (13) | 37 (12) | 0.5730 |
| Presence of baseline TFR | 35 (9) | 41 (13) | 0.0660 |
| Presence of synovitis on any exam | 84 (21) | 68 (22) | 0.7820 |
| Deceased | 124 (31) | 131 (44) | 0.0010 |
| Serology | |||
| Any ThTo Component (hPOP1, RPP25 RPP30, or RPP40) | 36 (9) | 23 (7) | 0.4950 |
| hPOP1 | 36 (9) | 22 (7) | 0.4090 |
| RPP25 | 23 (6) | 12 (4) | 0.2970 |
| RPP30 | 24 (6) | 20 (6) | 0.8760 |
| RPP40 | 31 (8) | 23 (7) | 1.0000 |
RP=Raynaud’s phenomenon, SSc=systemic sclerosis, TFR=tendon friction rubs.
*
Excluding non-melanotic skin cancers