Fig. 4.
Iso- or forskolin-induced HDAC4 nuclear accumulation is PKA-dependent. Average values of HDAC4 FNuc/FCyto under PKA signaling agonists in the absence or presence of specific PKA inhibitor H-89 (a) or PKI (b). Cells were incubated with indicated drugs for 30 min at 37 °C. c Average values of HDAC4 FNuc/FCyto ratio under PKA signaling agonists with or without 30 min preincubation with specific CaMKII inhibitor KN93. d Average values of HDAC4 FNuc/FCyto under PKA signaling agonists in the absence or presence of H-89 in WT and CAMKIIδ knockout (KO) mice. ***p < 0.0001 and **p < 0.001 vs. baseline; #p < 0.01 vs. WT