Figure 5.

Both Th1 and Th2 cell responses are impaired in S. japonicum‐infected mice with CD1d overexpression. (A) Representative FCM dot plots (left), average percentages (middle) and absolute numbers (right) for IFN‐γ‐(Th1)‐ and IL‐4‐(Th2)‐producing CD3⁺CD4⁺ T cells, and CD3⁺CD4⁺CD25⁺Foxp3⁺ Treg cells from the livers of normal or S. japonicum‐infected mice. (B–D) Representative FCM dot plots (left), average percentages (middle) and absolute numbers (right) for IFN‐γ‐(Th1)‐ and IL‐4‐(Th2)‐producing CD3⁺CD4⁺ T cells (B and C), and CD3⁺CD4⁺CD25⁺Foxp3⁺ Treg cells (D) from the livers of S. japonicum‐infected mice injected with AAV‐CD1d or AAV‐Ctrl. Data are means ±SD from 5 mice per group and representative of two independent experiments. *P < 0.05, **P < 0.01 and ***P < 0.001; ns, not significant.