Table 2.

The correlation between cytokines produced by TLR‐activated CD4⁺ and CD8⁺ T cells and neurological disabilities in RRMS patients

	Pam3C		LPS
	r	p	r	p
CD4+ T cells
IL−1β	0.3986	0.0817	0.2190	0.3535
IL−6	0.5633	0.0097	0.6013	0.0050
TNF‐α	0.3669	0.1116	0.1814	0.4440
IFN‐γ	0.5390	0.0142	0.3989	0.0814
IL−17	0.5725	0.0083	0.6175	0.0037
IL−21	0.4807	0.0319	0.3344	0.1496
IL−22	0.3001	0.1988	0.3165	0.1740
GM‐CSF	0.3515	0.1285	0.3391	0.1486
IL−10	−0.5013	0.0243	−0.7282	0.0003
CD8+ T cells
IL−1β	0.2973	0.2031	0.2639	0.2608
IL−6	0.5053	0.0231	0.6143	0.0040
TNF‐α	0.2165	0.3593	0.3753	0.1030
IFN‐γ	0.1905	0.4212	0.3783	0.1431
IL−17	0.4905	0.0281	0.3970	0.0831
IL−21	0.2601	0.2681	0.3166	0.1738
IL−22	0.0569	0.8115	0.2410	0.3060
GM‐CSF	0.2686	0.2522	0.3701	0.1084
IL−10	−0.2538	0.2803	0.1175	0.6217

The levels of different cytokines produced by CD4⁺ and CD8⁺ T‐cell cultures maintained for 48 h in the presence of Pam3C (TLR2 agonist) and LPS (TLR4 agonist) were correlated with neurological disabilities, determined by EDSS score, in 20 RRMS patients (10 without and 10 MDD).

Bold indicate significant values after comparison (p <0.05).