Table 2.

Results of univariate and multivariate analysis of predictors for overall survival (OS) in the overall population (n = 573).

Characteristic	Categories	Univariate analysis			Multivariate analysis
		Median OS (95% CI), mo	HR (95% CI)	P value	HR (95% CI)	P value
Age at diagnosis	<50 y (n = 192)	70.8 (55.5–86.1)	0.94 (0.73–1.23)	0.693	1.17 (0.77–1.77)	0.460
	≥50 y (n = 381)	68.6 (59.3–77.8)
Sex	Male (n = 335)	75.5 (65.7–85.3 m)	0.75 (0.59–0.95)	0.021	0.88 (0.66–1.17)	0.393
	Female (n = 238)	58.9 (47.4–70.3)
RAS status	Mutated (n = 255)	52.5 (45.2–59.7)	1.74 (1.36–2.22)	<0.001	1.58 (1.23–2.03)	<0.001
	Wild-type (n = 318)	78.4 (66.0–90.8)
BRAF status	Mutated (n = 9)	47.2 (3.7–90.7)	1.32 (0.54–3.21)	0.536	2.01 (0.60–6.66)	0.252
	Wild-type (n = 456)	72.2 (63.4–81.0)
MSI status	MSI-H (n = 9)	Not reached	0.32 (0.04–2.30)	0.259	0.28 (0.03–2.09)	0.218
	MSS (n = 354)	81.4 (67.8–95.0)
Sidedness	Right (n = 146)	54.2 (47.7–60.7)	1.63 (1.26–2.12)	<0.001	1.57 (1.20–2.05)	0.001
	Left (n = 427)	76.3 (65.3–87.2)
CEA level > 10 ng/mL	Yes (n = 141)	64.5 (54.1–75.0)	1.19 (0.90–1.56)	0.211	1.15 (0.72–1.83)	0.535
	No (n = 414)	72.0 (62.9–81.2)
≥2 liver lesions	Yes (n = 263)	61.1 (50.3–71.8)	1.26 (0.99–1.60)	0.057	0.88 (0.58–1.33)	0.565
	No (n = 294)	77.9 (69.2–86.6)
pCR	Yes (n = 21)	90.2 (40.4–139.9)	0.59 (0.28–1.27)	0.182	0.63 (0.28–1.43)	0.278
	No (n = 416)	67.3 (57.5–77.2)
Margin status	Positive (n = 91)	66.6 (51.3–82.0)	0.89 (0.73–1.43)	0.894	1.16 (0.65–2.04)	0.607
	Negative (n = 481)	70.6 (61.4–79.8)
Extrahepatic disease	Yes (n = 103)	46.0 (32.5–59.5)	1.62 (1.21–2.17)	0.001	1.54 (1.15–2.07)	0.004
	No (n = 470)	72.2 (63.7–80.7)
Postoperative therapy	Yes (n = 385)	77.8 (67.6–88.0)	0.66 (0.51–0.85)	0.001	0.66 (0.51–0.85)	0.001
	No (n = 177)	57.1 (48.3–65.8)

CEA carcinoembryonic antigen, HR hazard ratio, MSI microsatellite instability, MSI-H high-frequency MSI, MSS microsatellite stable, pCR pathologic complete response.

p < 0.05 was considered statistically significant.