Table 3.

Results of univariate and multivariate analysis of predictors for overall survival (OS) in patients with EOCRC (n = 192).

Characteristic	Categories	Univariate analysis			Multivariate analysis
		Median OS (95% CI), mo	HR (95% CI)	P value	HR (95% CI)	P value
Sex	Male (n = 99)	70.8 (48.8–92.8)	0.82 (0.53–1.27)	0.384	1.08 (0.60–1.94)	0.782
	Female (n = 93)	71.2 (48.8–92.8)
RAS status	Mutated (n = 77)	53.3 (44.5–62.1)	2.03 (1.30–3.17)	0.002	1.90 (1.20–3.02)	0.006
	Wild-type (n = 115)	82.9 (52.3–113.4)
BRAF status	Mutated (n = 5)	111.6 (0.0–∞)	1.22 (0.38–3.93)	0.730	1.18 (0.34–4.04)	0.784
	Wild-type (n = 163)	68.4 (53.7–83.2)
MSI status	MSI-H (n = 3)	Not reached	0.04 (0.0–82.8)	0.424	0.0 (0.0–∞)	0.969
	MSS (n = 150)	72.0 (53.3–90.8)
Sidedness	Right (n = 37)	47.8 (24.8–70.8)	1.84 (1.11–3.02)	0.016	1.71 (0.99–2.94)	0.050
	Left (n = 155)	81.7 (58.5–105.0)
CEA level > 10 ng/mL	Yes (n = 40)	71.2 (41.9–100.5)	1.10 (0.65–1.87)	0.698	1.23 (0.62–2.45)	0.544
	No (n = 143)	68.4 (53.0–83.8)
≥2 liver lesions	Yes (n = 83)	56.4 (39.4–73.4)	1.48 (0.95–2.30)	0.077	1.60 (1.02–2.49)	0.038
	No (n = 102)	72.2 (52.5–91.9)
pCR	Yes (n = 11)	90.2 (0.0–∞)	0.63 (0.19–2.01)	0.438	0.57 (0.13–2.41)	0.446
	No (n = 147)	70.8 (54.8–86.8)
Margin status	Positive (n = 35)	72.2 (0.0–∞)	0.85 (0.48–1.52)	0.597	1.06 (0.53–2.12)	0.856
	Negative (n = 157)	68.4 (51.8–85.1)
Extrahepatic disease	Yes (n = 51)	53.3 (33.1–73.5)	1.76 (1.11–2.80)	0.015	1.64 (1.00–2.66)	0.046
	No (n = 141)	72.2 (60.2–84.2)
Postoperative therapy	Yes (n = 125)	72.2 (44.0–100.4)	0.71 (0.44–1.12)	0.144	0.64 (0.40–1.02)	0.064
	No (n = 58)	59.5 (43.8–75.1)

CEA carcinoembryonic antigen, HR hazard ratio, MSI microsatellite instability, MSI-H high-frequency MSI, MSS microsatellite stable, pCR pathologic complete response.

p < 0.05 was considered statistically significant.