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. 2020 Nov 24;124(4):728–735. doi: 10.1038/s41416-020-01151-6

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Plasma concentration–time profiles of peposertib (formerly M3814) following a QD (PK Analysis Set; n = 6) and b BID (PK Analysis Set; n = 25 [Cycle 1], n = 17 [Cycle 2]) dosing (linear scale). Dose-normalised AUC_0–12 for peposertib by dose on c Cycle 1 Day 1 (QD and BID; PK Analysis Set; n = 25) and d Cycle 2 Day 1 (BID; PK Analysis Set; n = 17). AUC_0–12 area under the plasma concentration–time curve from 0 to 12 h, BID twice daily, PK pharmacokinetics, QD once daily.