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. 2020 Nov 24;124(4):728–735. doi: 10.1038/s41416-020-01151-6

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Peposertib (formerly M3814) dose (mg)/frequency of administration is shown for each patient on the x axis. Dashed lines show the 20% threshold for PD and the 30% threshold for partial response. ^aColon. BID twice daily, MSI microsatellite instability, NSCLC non-small cell lung cancer, PD progressive disease, QD once daily, RP2D recommended phase 2 dose, SD stable disease.