Table 1.
Association of rs45446698 with levels of oestrone-3-glucuronide, pregnanediol-3-glucuronide and progesterone in premenopausal women of European ancestry.
| Hormone | Geometric mean by rs45446698 genotype (µmol/mol) | Unadjusted analysis | Adjusted analysisa | |||
|---|---|---|---|---|---|---|
| AA | AC/CC | % change | P | % change | P | |
| GWAS (N = 560) | ||||||
| Oestrone-3-glucuronide | 9.74 | 4.95 | −49.2 (−56.1 to −41.1) | 3.1 × 10–18 | −44.8 (−53.3 to −34.8) | 2.1 × 10–12 |
| Pregnanediol-3-glucuronide | 0.78 | 0.70 | −10.1 (−22.5 to 4.3) | 0.16 | −9.3 (−22.9 to 6.8) | 0.24 |
| Follow-up progesterone analysis (N = 298) | ||||||
| Oestrone-3-glucuronide | 9.77 | 4.39 | −55.0 (−63.1 to −45.1) | 2.6 × 10–15 | −55.1 (−63.6 to −44.7) | 4.0 × 10–14 |
| Pregnanediol-3-glucuronide | 0.79 | 0.75 | −5.5 (−24.2 to 17.7) | 0.61 | −9.6 (−27.9 to 13.3) | 0.38 |
| Progesterone | 29.37 | 21.51 | −26.7 (−39.4 to −11.6) | 0.001 | −24.3 (−37.6 to −8.2) | 0.005 |
aAnalysis was adjusted for age at menarche (<12, 12, 13, 14 and >14 years), age at collection of urine samples (<35, 35–40 and ≥40 years), body mass index (<18.5, 18.5–<20.0, 20.0–<25.0, 25.0–<30.0 and ≥30.0 kg/m2) and parity (0, 1, 2 and ≥3 live births).