. 2021 Jan 26;124(4):842–854. doi: 10.1038/s41416-020-01185-w

Table 2.

Association of rs45446698 among women of European ancestry overall and stratified by hormone receptor status.

	iCOGS				OncoArray				Combined
	Cases	Controls	OR (95% CI)	P₁	Cases	Controls	OR (95% CI)	P₁	Cases	Controls	OR (95% CI)	P₁
All subjects	36,859	37,320	0.93 (0.87–0.98)	0.01	54,057	52,573	0.95 (0.91–1.00)	0.05	90,916	89,893	0.94 (0.91–0.98)	0.002
												P_het = 0.58
ER +	19,950	28,820	0.90 (0.84–0.97)	0.007	28,478	40,223	0.92 (0.87–0.98)	0.01	48,428	69,043	0.91 (0.87–0.96)	0.0002
ER−	4298	28,820	1.04 (0.92–1.18)	0.56	6592	40,223	1.03 (0.92–1.14)	0.64	10,890	69,043	1.03 (0.95–1.11)	0.50
NK	5087				8380
Total	29,335	28,820		P_int = 0.06	4450	40,223		P_int = 0.19				P_int = 0.03
PR +	13,995	28,820	0.85 (0.78–0.93)	0.0002	21,500	40,223	0.87 (0.81–0.93)	0.0001	35,495	69,043	0.86 (0.82–0.91)	5.8 × 10^–8
PR−	6154	28,820	1.06 (0.95–1.18)	0.33	10,058	40,223	1.05 (0.96–1.15)	0.26	16,212	69,043	1.05 (0.98–1.12)	0.18
NK	9186				11,892
Total	29,335	28,820		P_int = 0.001	43,450	40,223		P_int = 0.0004				P_int = 1.3 × 10^–6
ER + , PR +	13,508	28,820	0.85 (0.78–0.93)	0.0003	20,624	40,223	0.87 (0.81–0.93)	0.0001	34,132	69,043	0.86 (0.82–0.91)	6.9 × 10^–8
ER + , PR−	2890	28,820	1.03 (0.89–1.20)	0.66	4597	40,223	1.07 (0.96–1.21)	0.21	7487	69,043	1.06 (0.96–1.16)	0.25
NK	12,937				18,229
Total	29,335	28,820		P_int = 0.02	43,450	40,223		P_int = 0.001				P_int = 0.0001

P₁ test of H₀ no association between rs45446698 and breast cancer risk, P_int test of H₀ no difference between stratum-specific estimates, P_het test of H₀ no difference between iCOGS and OnocoArray data, NK not known.

Studies with less than 50 cases in any stratum were excluded from the stratified analyses leaving 16 studies for analysis in iCOGS data and 32 studies for analysis in OncoArray data.