Table 4.
Association of rs45446698 with breast cancer-specific survival in breast cancer cases of European Ancestry stratified by treatment regimen.
| Group | iCOGS | OncoArray | Combined | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Cases | Events | HR (95% CI) | P1 | Cases | Events | HR (95% CI) | P1 | HR (95% CI) | P1 | Phet | |
| All breast cancer patients | 32,743 | 2580 | 0.93 (0.80–1.08) | 0.35 | 58,796 | 3799 | 1.04 (0.92–1.17) | 0.57 | 0.99 (0.91–1.09) | 0.90 | 0.28 |
| Only patients that | |||||||||||
| Received tamoxifen | 9766 | 825 | 1.22 (0.95–1.57) | 0.13 | 7803 | 746 | 0.95 (0.73–1.23) | 0.68 | 1.08 (0.90–1.30) | 0.41 | 0.18 |
| Received aromatase inhibitor | 3794 | 246 | 0.94 (0.58–1.54) | 0.82 | 5460 | 247 | 1.03 (0.64–1.65) | 0.91 | 0.99 (0.70–1.39) | 0.94 | 0.81 |
| Received CMF-like CT | 919 | 99 | 0.30 (0.09–1.01) | 0.05 | 1692 | 229 | 0.88 (0.55–1.41) | 0.60 | 0.77 (0.50–1.19) | 0.24 | 0.11 |
| Received taxanes* | 1806 | 160 | 1.69 (0.96–2.99) | 0.07 | 3836 | 299 | 1.37 (0.96–1.96) | 0.08 | 1.46 (1.08–1.97) | 0.01 | 0.54 |
| Received anthracycline therapy | 4625 | 418 | 1.21 (0.83–1.75) | 0.32 | 6740 | 771 | 1.07 (0.82–1.38) | 0.63 | 1.11 (0.90–1.37) | 0.33 | 0.58 |
CMF cyclophosphamide methotrexate fluorouracil, CT chemotherapy, P1 test of H0 no association between rs45446698 and breast cancer-specific survival, Phet test of H0 no difference across genotyping platforms.
In total, 38 studies from iCOGS and 63 studies from OnocoArray provided follow-up data for analysis of breast cancer-specific survival. The results were censored at 10 years after diagnosis. HR for association of rs45446698 genotype with breast cancer-specific survival was estimated using Cox proportional hazards regression stratified by country.
*To test for statistical interaction between rs45446698 genotype and treatment with a taxane, we additionally compared the association in cases who received chemotherapy including a taxane to that in cases who received chemotherapy that did not include a taxane (Pint = 0.02; the association in the latter group was in the opposite direction and not significant: HR = 0.88, 95% CI 0.67–1.15, P = 0.34).