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. 2021 Feb 15;11:3814. doi: 10.1038/s41598-021-83432-5

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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MCAO resulted in acute functional gait deficits. At 2d and 8d post-MCAO, MCAO pigs exhibited significant decreases in velocity (a), cadence (a), stride length (b), step length (b), swing percent (c), and an increase in stance percent (c) relative to pre-MCAO values. At 15d and 27d post-MCAO, there were no significant differences compared to pre-stroke, which was indicative of functional recovery (p > 0.05). At 2d post-MCAO, MCAO pigs exhibited significantly different velocity (a), cadence (a), stride length (b), and step length (b) relative to non-stroked controls. Non-stroked controls had no significant changes over the course of the study (p > 0.05). * and ** indicated statistical difference from pre-MCAO values. # and ## indicated statistically different between groups.