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. 2021 Feb 15;11:3837. doi: 10.1038/s41598-021-83370-2

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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(a) Hippocampal sub-regions. (b) Predetermined region-of-interest (ROI) in the Dentate Gyrus used to evaluate the effect of flavanol consumption by Cerebral Blood Volume (CBV)-fMRI. (c) Changes in CBV-fMRI before and 12 weeks after daily intake of placebo and flavanols at a low (260 mg), medium (510 mg) and high (770 mg) intake level. Data are expressed as mean ± SE adjusted by baseline values.