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. 2021 Feb 15;11:3837. doi: 10.1038/s41598-021-83370-2

Table 3.

Test of differential effects between treatment groups on the List-Learning task at week 12 at different tertiles divided according to alternative Healthy Eating Index (aHEI), controlling for baseline list learning, sex, age, and education.

Between Groups Low aHEI at Baseline Medium aHEI at Baseline High aHEI at Baseline
Tests between Intake amounts Adj Mean Diff SE Cohen's d Effect sizea pb Adj Mean Diff SE Cohen's d Effect sizea pb Adj Mean Diff SE Cohen's d Effect sizea pb
Low flavanol intake vs Placebo 1.251 1.846 0.148 0.499 1.673 2.366 0.198 0.480 − 0.022 2.1 − 0.003 0.992
Medium flavanol intake vs Placebo 2.621 2.047 0.31 0.202 0.078 2.109 0.009 0.971 1.028 2.11 0.122 0.627
High flavanol intake vs Placebo 5.268 2.085 0.623 0.012 − 1.676 1.891 − 0.198 0.377 4.355 2.29 0.515 0.059
Trend Test across intake amounts 0.011 0.271 0.051
Interaction test (aHEI vs intake amount) F-test (6,186) = 1.87, p = 0.088

Bold value indicates p < 0.05.

aCohen’s d effect size calculated taking Adj Mean Diff divided by baseline measures standard deviation.

bTwo-sided p value for t-test of treatment at each intake amount compared to placebo from longitudinal mixed effects model.

Adj Mean Diff, adjusted mean difference;