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. 2021 Feb 15;6:13. doi: 10.1038/s41525-021-00177-w

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Kaplan–Meier curves of OS and RFS for each group are shown. a, b Patients with high median.hERV develop resistance to chemotherapy. c, d Clinicopathological factors can predict survival outcome. clinicopathological− is defined as patients with unfavorable age (top 30%), or stage (III), or sidedness status (right). e, f Incorporating median.hERV and CD8+ biomarkers can further stratify patients with poor clinical outcome (log-rank P values are shown). CD8−/hERV+ subgroup is labeled as WTS− as opposed to WTS+ which composes CD8+/hERV+, CD8−/hERV−, and CD8+/hERV− subgroups.