Fig. 4. HERVs establish a distinct molecular subtype in CRC.

a CMS classification defines CMS1-4 for patients in this cohort. b hERVs are abundant in all CMSs. Heatmaps in a and b represent Z-scores for genes with FDR < 0.05 and FDR < 0.01. c Mutational and copy number profile, MSI and LS status for each CMS observed in this cohort. d Enrichment analysis portraits clinicopathological and immuno-phenotypical characteristic of each CMS. e Heatmap shows the frequency of each gene mutations per CD8/hERV subgroup. f Kaplan–Meier curves of RFS for each group are shown. Incorporation of median.hERV into CMS classification boosts the predictive power CMS (log-rank P values are shown).