Table 3.
Clinical and biological characteristics of 272 HPV-positive cervical cancer, in relation to HPV copy number.
| Number of patients (%) | ||||
|---|---|---|---|---|
| HPV copy numbera | Patients (%) | Low HPV copy number (<4) | High HPV copy number (≥4) | p valueb |
| Total | 272 (100.0) | 145 | 127 | |
| Age | ||||
| ≤50 | 140 (51.5) | 72 (49.7) | 68 (53.5) | 0.52 (NS) |
| >50 | 132 (48.5) | 73 (50.3) | 59 (46.5) | |
| Histologic subtype | ||||
| Squamous cell carcinoma | 230 (84.6) | 116 (80.0) | 114 (89.8) | 0.14 (NS) |
| Adenocarcinoma | 27 (9.9) | 19 (13.1) | 8 (6.3) | |
| Adenosquamous carcinoma | 10 (3.7) | 6 (4.1) | 4 (3.1) | |
| Mixed form or undifferenciated | 5 (1.8) | 4 (2.8) | 1 (0.8) | |
| HPV status | ||||
| Genotype 16 | 155 (57.0) | 60 (41.4) | 95 (74.8) | <0.0001 |
| Genotype 18 | 36 (13.2) | 28 (19.3) | 8 (6.3) | |
| Genotype 45 | 27 (9.9) | 25 (17.2) | 2 (1.6) | |
| Genotype 31 | 9 (3.3) | 6 (4.1) | 3 (2.4) | |
| Genotype 33 | 11 (4.0) | 4 (2.8) | 7 (5.5) | |
| Other genotypesc | 34 (12.5) | 22 (15.2) | 12 (9.4) | |
| Stage FIGO | ||||
| I/II | 205 (75.4) | 103 (71.0) | 102 (80.3) | 0.076 (NS) |
| III/IV | 67 (24.6) | 42 (29.0) | 25 (19.7) | |
| Lymph node | ||||
| Yes | 167 (61.4) | 101 (69.7) | 66 (52.0) | 0.0028 |
| No | 105 (38.6) | 44 (30.3) | 61 (48.0) | |
| Pelvis lymph node | ||||
| Yes | 165 (60.7) | 100 (69.0) | 65 (51.2) | 0.0027 |
| No | 107 (39.3) | 45 (31.0) | 62 (48.8) | |
| Para-aortic lymph node | ||||
| Yes | 43 (15.8) | 28 (19.3) | 15 (11.8) | 0.091 (NS) |
| No | 229 (84.2) | 117 (80.7) | 112 (88.2) | |
| Initial therapy | ||||
| Surgery | 54 (19.9) | 30 (20.7) | 24 (18.9) | 0.58 (NS) |
| Radiotherapy | 176 (64.7) | 90 (62.1) | 86 (67.7) | |
| Neoadjuvant chemotherapy | 42 (15.4) | 25 (17.2) | 17 (13.4) | |
| PIK3CA mutational statusd | ||||
| WT | 182 (67.7) | 101 (71.1) | 81 (63.8) | 0.20 (NS) |
| Mutated | 87 (32.3) | 41 (28.9) | 46 (36.2) | |
| HPV insertione | ||||
| EPI | 33 (12.1) | 9 (6.2) | 24 (18.9) | <0.0001 |
| 2J | 117 (43.0) | 104 (71.7) | 13 (10.2) | |
| MJ | 122 (48.9) | 32 (22.1) | 90 (70.9) | |
Significant results are displayed in bold
NS not significant.
aHPV copy number is a ratio of the number of reads of HPV over control human gene KLK3.
bChi-square test.
cOther genotypes.
dInformation available for 269 patients.
eHPV insertion: EPI episomal, 2J 2 junctions, MJ multiple junctions.