Table 2.

Comparison of different populations of T cells from Babraham pigs infected with H1N1pdm09 virus.

% T cells binding to tetramer or/cytokineproducing		Days Post Infection (DPI)
		6 DPI	7DPI	13 DPI
CD8β	NP290-298	no significant (P>0.05) differences*	BAL†>PBMC (P=0.01) lung>PBMC (P=0.04) lung>TBLN (P=0.04)	BAL>lung (P=0.04) BAL>TBLN (P=0.01) BAL>PMBC (P=0.01) lung>PMBC (P=0.01) TBLN>PMBC (P=0.01)
CD8β	IFNγ	BAL>PBMC (P=0.01) BAL>TBLN (P=0.01) lung>PBMC (P=0.01) lung>TBLN (P=0.03)	BAL>PBMC (P=0.01) BAL>TBLN (P=0.01) lung>PBMC (P=0.01) lung>TBLN (P=0.03)	BAL>PBMC (P=0.01) BAL>TBLN (P=0.01) lung>PBMC (P=0.01) lung>TBLN (P=0.03)
	IL-2	no significant (P>0.05) differences	BAL> lung (P=0.06) BAL>PBMC (P=0.02) BAL>BM TBLN (P=0.02)	BAL>lung (P=0.01) BAL>PBMC (P=0.01) BAL>TBLN (P=0.01)
	TNF	BAL>lung (P=0.01) BAL>PBMC (P=0.01) BAL>TBLN (P=0.01) lung>PBMC (P=0.02)	BAL>lung (P=0.02) BAL>PBMC (P=0.01) BAL>TBLN (P=0.01) lung>PBMC (P=0.02)	BAL>lung (P=0.01) BAL>PBMC (P=0.01) BAL>TBLN (P=0.01) lung>PBMC (P=0.02) lung>TBLN (P=0.06)
CD4	IFNγ	no significant (P>0.05) differences	lung>TBLN (P=0.02) lung>PBMC (P=0.01)	BAL>PBMC (P=0.06) lung>PBMC (P=0.06)
	IL-2	BAL>PBMC (P=0.01) lung>PBMC (P=0.03) TBLN>PBMC (P=0.01)	BAL>PBMC (P=0.01) lung>PBMC (P=0.01) TBLN>PBMC (P=0.01)	BAL>PBMC (P=0.01) lung>PBMC (P=0.01) TBLN>PBMC (P=0.01)
	TNF	no significant (P>0.05) differences	no significant (P>0.05) differences	BAL>PBMC (P=0.06) TBLN> lung (P=0.06) TBLN>PBMC (P=0.02)

*P-values based on pairwise Wilcoxon rank-sum tests following a significant (P<0.05) Kruskal-Wallis test.

^†BAL, broncho-alveolar lavage; PBMC, peripheral blood mononuclear cell; TBLN, tracheobronchial lymph node.