Skip to main content
. 2021 Feb 2;10:609071. doi: 10.3389/fcimb.2020.609071

Figure 1.

Figure 1

Schematic diagram of the CAV, PCV and DuCV gene structures. (A) The relative localizations of three major ORF proteins in CAV, PCV, and DuCV differ from each other. In particular, the ORF3 proteins of PCV and DuCV are oriented in the direction opposite that of Rep gene, in contrast to the ORF3 protein in CAV. (B) The ORF3 protein structures between DuCV1 and DuCV2 differ. The DuCV2 ORF3 (99 aa) is 20 aa longer than that of DuCV 1, in which an NLS has been identified. (C) The ORF3 structures between PCV1 and PCV2 differ. The length of the ORF3 is 315 bp in PCV2, while in PCV1, it is approximately 612 bp. The NES has been identified in the N-terminus of PCV2 ORF3 protein at residues 1–35, and a bipartite NLS was found at residues 53–68 and 85–104. (D) The primary structures of the CAV ORF3 protein (Los et al., 2009). The following main domains are shown in color: leucine-rich region (blue), phosphorylation site (red), bipartite nuclear localization sequences (green), and nuclear export sequence (yellow).