Table 1.
Characteristics of adenocarcinomas and benign nodules in the primary and validation cohorts.
| Characteristic | Primary cohort (n = 98) | Validation cohort (n = 43) | ||||
|---|---|---|---|---|---|---|
| Adenocarcinoma (n = 50) | Benign (n = 48) | P | Adenocarcinoma (n = 22) | Benign (n = 21) | P | |
| Gender | 0.69 | 0.55 | ||||
| Female | 22 | 19 | 9 | 11 | ||
| Male | 28 | 29 | 13 | 10 | ||
| Age (years) | 61.32 ± 1.30 | 53.96 ± 1.44 | 0.0003 | 65.45 ± 1.70 | 53.33 ± 1.59 | <0.0001 |
| Lung-RADS category | ||||||
| 2, 3 | 2 | 27 | 0 | 14 | ||
| 4A, 4B, 4X | 48 | 21 | 22 | 7 | ||
| Histologic subtype | ||||||
| Inflammation | 17 | 10 | ||||
| Granulomas | 17 | 7 | ||||
| Hamartoma | 6 | 1 | ||||
| PSP | 5 | 0 | ||||
| Other benign entities | 3 | 3 | ||||
Age is shown in means ± standard deviation, and the other data are the number of nodules. Granulomas are caused by Mycobacterium tuberculosis, Cryptococcus neoformans, and other unspecified conditions. Other benign entities include intrapulmonary lymph node, fibroplasia, and lymphoid hyperplasia. Lung-RADS, Lung CT Screening Reporting and Data System; PSP, pulmonary sclerosing pneumocytoma.